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《Journal of Chinese Physician》 2003-03
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Interfering Effect of Glutathione on Pulmonary Fibrosis in Rats

CHAI Wen-shu,LI Yong-chun,LI Yan-qin ,et al.Department of Respiratory Medicine,The First Affiliated Hospital,Jinzhou Medical College ,Jinzhou,121001,China  
Objective To observe the effect of glutathione on bleomycin-induced pulmonary fibrosis in rats .Methods Fifty-four SD rats in good conditions were divided into three groups at random:control group ,BLM group,glutathione(GSH) group.On experimental day(day 0),the rats were intratracheally instilled with bleomycin(5mg·kg -1 .body weight),and then treated with intraperitoneal injection of glutathione .On days 7,14,28 after instillation ,six rats of each group were sacrified respectively and the lungs were harvested for histopathological examination and determinations of GSH and hydroxyproline(HYP).Results Pathological findings of GSH group were the same as BLM group,but compared with BLM group,pathomorphologic changes in GSH group was a small extent.The content of GSH in lung tissue was increased significantly(P0 01),whereas the content of HYP was nearly the same as the BLM group satistically(P0 05).Conclusions Glutathione has anti-oxidation and may protect lung tissue free from oxidation injury, but it has no protecting effect on collagen deposition caused by bleomycin.
【Fund】: 辽宁省教育厅资助项目 (980 52 1 1 0 52 )
【CateGory Index】: R-332
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