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《Journal of Chinese Physician》 2003-03
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Observation on Serum IL-8 Levels of Acute Lung Injury and Acute Respiratory Distress Syndrome

XIE Han-hua,WU Xiao-hua,YAO Yin.Department of Respiratory Medicine,The Affiliated Yanzhou Municipal First People's Hospital, Yanzhou University,Yanzhou,225001,China  
Objective To display whether Interleukin-8 was involved in acute lung injury(ALI) and in acute respiratory distress syndrome(ARDS).Methods Serum IL-8 levels in 12 patients with ALI and 13 patients with ARDS were assayed by RIA,and compared with 59 normal controls.Results The level of serum IL-8 was significantly higher in the patients with ALI and ARDS than that in the normal controls(P0 01),the level of serum IL-8 was also significantly higher in the patients with ARDS than that in the patients with ALI(P0 05),and the level of serum IL-8 was significantly higher in the non-survivors than in the survivors among the patients with ALI and ARDS(P0 01).Conclusions These findings indicated that IL-8 is involved in the inflammatory reaction of ALI and ARDS,high levels of serum IL-8 could predict a poor prognosis,for the patients with ALI or with ARDS.
【CateGory Index】: R563.8
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