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《Journal of Chinese Physician》 2003-11
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Effect of Dexamethasone with Subdose Ketamine on Restraining the Pulling-dragging Reflex During Appendectomy

MIAO Shao-hua,ZHU Hong-xia.Department of Anesthesiology, Hospital of Heze City, Heze 274031,China  
Objective To investigate the effect of dexamethasone with subdose ketamine on restraining the pulling-dragging reflex during appendectomy. Methods 114 ASA grade Ⅰ~Ⅱpatients of appendectomy undergoing T 11 ~L 1 epidural anesthesia were randomly divided three groups,each group containing 38 cases. Group Ⅰ recieved the dexamethasone 10mg and ketamine 0 5mg/kg by venous injection before opening abdominal cavity, groupⅡ received pethidine 50mg and droperidol 2 5mg before begining operation, and group Ⅲ without any drugs served as control. The pulling-dragging reflex of appendix, the sedative state at pulling-dragging appendix and the change of pulse oxygen saturation (SpO 2) or mean arterial pressure (MAP) were recorded and analyzed. Results The excellent rates of groupsⅠ, Ⅱ and Ⅲ were 100%, 81 58% and 18 42% respectively,and there was significant difference between group I and the other groups (P0 01). The sedative state was similar between groupsⅠ and Ⅱ, but the sedative state of groups I and II was better than that of groupⅢ (P0 01). The SpO 2 and MAP had not significant difference before and affter giving the drugs in group I, but the SpO 2 and MAP of group I were better than those of group II (P 0 05). Conclusions Dexamethasone with subdose ketamine can effectively restrain the pulling-dragging reflex of appendix.
【CateGory Index】: R614
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