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《Journal of Chinese Physician》 2003-S1
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Effect of Small and Large Ambroxol on Pulmonary Surfactant in Asthma Guinea-pig

ZHENG Yan-hui,KUAN Shou-jing.Department of Pediatvics The 3rd Xiang Hospital,Central South University,Changsha,410013,China  
Objective To observe effect of small and large ambroxol on pulmonary surfactant in asthma guinea-pig. Methods 24 guinea-pigs were randomly divided into 4 groups;normal control group,asthma group, small dose ambroxol(7.5mg/kg.d)treated group, large dose ambroxol(30mg/kg.d)treated group. We detected total phospholipids(TPL),desaturated phosphatidylcholine(DSPC),total protein(TP) in broncho-alveolar lavage fluid(BALF).Results The levels of DSPC/TP? DSPC/TPL and DSPC of asthma group were statistically lower than normal control group P 0.01.In contrast, the levels of TP of asthma group were obviously higher as compared with it P 0.01.The levels of DSPC/TP,DSPC/TPL and DSPC of ambroxol treaded groups, small and large ambroxol treated group , which were similar to each other on DSPC/TP,DSPC/TPL,DSPC and TP( P 0.05),were statistically higher than asthma group( P 0.01), the levels of TP of them were obviously lower compared with asthma group P 0.01.Conclusions Ambroxol can promote in synthesize and secretion of PS .Small dose ambroxol can play a role as good as large dose ambroxol.
【CateGory Index】: R562.25
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Chinese Journal Full-text Database 2 Hits
1 DAI Jihong, TAN Yi, FU Zhou (Children's Hospital of Chonqing University of Medical Science, Chonqing 400014,China);The Current Situation of Researches on Animal Model of Asthma[J];Chinese Journal of Laboratory Animal Science;2001-03
2 ZHAO Shi fen, ZHANG Qing rong,XIA Shu jie,LIN Shu ru, GU Feng (Basic Medical Department of Liaoning College of TCM(Shenyang 110032);Influence of Yiqi Dingchuan Decoction on Antioxidant ability of Alvoelar Macrophages in Guinea pigs with Asthma[J];CHINA JOURNAL OF BASIC MEDICINE IN TRADITIONAL CHINESE MEDICINE;2000-02
Chinese Journal Full-text Database 3 Hits
1 ZHENG Yan-hui1,ZHENG Bing2(1.Changsha Railway Hospital of hunan province,Hunan Changsha 410001,China; 2.Hunan Institute of Traditional Chines Medtcine,Hunan Changsha 410013, China);Effect of ambroxol on airway reaction in the guinea-pig with asthma[J];Journal of Pediatric Pharmacy;2004-05
2 Liu SZ,Liu YL,Cao GL,Fang XB.1Hebei Tangshan Worker Hospital,Tangshan 063000,Hebei Province,China;2Department of Neurobiology,China Medical University,Shenyang 110001,Liaoning Province,China;Essentials of verifying immune inflammatory reaction in asthmatic animals[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2007-29
3 WANG Yong-sheng1,GUI Shu-yu2,LI Yong-huai2 (1 Respiratory Department,Chaohu First People′s Hospital,Chaohu 238002,China; 2 Respiratory Department,The First affiliated Hospital of Anhui Medical University,Hefei 230022,China);Establishment of rat model of allergic asthma and the effect of desamethasone on it[J];China Medical Herald;2007-22
Chinese Journal Full-text Database 10 Hits
1 CUI Hujun 1△ , ZHANG Mingli 1, XIAO Feng 1, LI Yan 1,WANG Jin 1, CHEN Hongyi 2 (1. Department of Cardiac surgery, 2. Department of Thoracic surgery, Peking University First Hospital, Beijing 100034, China);Comparison and correlative analysis of pulmonary function markers after extracorporeal circulation[J];Journal of Beijing Medical University;2003-02
2 DENG Lin 2, FANG Feng 1, FANG Chao Ping 1, WU Yong Zheng 1 (1. Department of Pediatrics, Changhai Hospital, Second Military Medical University, Shanghai 200433, China; 2. Department of Pediatrics, the First People′s Hospital of Yichang, Yichan;Effects of ambroxol on pulmonary surfactant system ultrastructure in asthma guinea pigs[J];ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY;2000-02
3 ZHAO Shuang-ping *,GUO Qu-lian,WANG Rui-ke,WANG E (ICU of Xiangya Hospital,Central South University,Changsha 410008,China);Oxidative and anti-oxidative effects of ambroxol on acute hydrochloric acid-induced lung injury in rats[J];;2004-05
4 WANG Chang tian, JING Hua, LI Zhong dong, HU Xiao nan, DONG Guo hua, LUO Li guo, GU Wei dong, SHEN Yi, XU Biao, QIAN Jian jun (Department of Cardiothoracic Surgery, Clinical School of Medical College of Nanjing University/Nanjing General Hospital of Nanjing Command, Nanjing 210002,Jiangsu,China);The effect of matrix metalloproteinase-9 in acute lung injury following cardiopulmonary bypass[J];Journal of Medical Postgraduates;2003-05
5 Zhang Qing,Yuan Shiying,Yao Shanglong.Department of Anesthesiology,Union Hospital, Tongji Medical College,Huazhong University of Science & Technology,Wuhan 430022 CHINA;The effect of high dose ambroxol on the antioxidant activity in patients with ARDS[J];The Journal of Clinical Anaesthesiology;2004-03
6 Luo Wenjie,Xue Qingsheng.Department of Anesthesiology,The People's Hospital of Putuo District,Shanghai 200060 CHINA;Preventive effect of ambroxol on postoperative respiratory complications in elderly patients undergoing upper abdominal surgery[J];The Journal of Clinical Anaesthesiology;2005-09
7 Liu Liqun,Jiang Ping,Xu Huamin,et al (10);The Effects of Pulsatile Candiopulmonary Bypass(CPB)on Pulmonary Leukoseqestration and Lipid Peroxidation[J];SHANDONG MEDICAL JOURNAL;1999-18
8 Chen Lanping, Zhang Yajun, Shi Donghui, et al. ICU of Affiliated Yancheng Hospital of Medical College of Southeast University,Yancheng 224001, China;Clinical study of effect of ambroxol on lung protection during heart operation under cardiopulmonary bypass[J];Chinese Journal of Cardiouascular Review;2005-03
9 XIE Jun-ran,ZENG Yin-ming (Jingsu Province Key Laboratory of Anesthesiology,Xuzhou Medical College, Xuzhou, Jiangsu 221002, China);The antioxidative action of dexamethasone and its protective effect on acute lung injury induced by lipopolysaccharide in rabbits[J];Acta Academiae Medicinae Xuzhou;2001-03
10 WANG Qiang, LIU Yinglong, LONG Cun, et al. Fuwai Hospital, CAMS & PUMC, Beijing 100037, China;Pulmonary artery perfusion with hypothermic solution reduces the lung injury of the children with pulmonary hypertension after cardiopulmonary bypass[J];Chinese Journal of Cardiology;2001-08
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