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《Journal of Chinese Physician》 2003-S1
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Effect of Small and Large Ambroxol on Pulmonary Surfactant in Asthma Guinea-pig

ZHENG Yan-hui,KUAN Shou-jing.Department of Pediatvics The 3rd Xiang Hospital,Central South University,Changsha,410013,China  
Objective To observe effect of small and large ambroxol on pulmonary surfactant in asthma guinea-pig. Methods 24 guinea-pigs were randomly divided into 4 groups;normal control group,asthma group, small dose ambroxol(7.5mg/kg.d)treated group, large dose ambroxol(30mg/kg.d)treated group. We detected total phospholipids(TPL),desaturated phosphatidylcholine(DSPC),total protein(TP) in broncho-alveolar lavage fluid(BALF).Results The levels of DSPC/TP? DSPC/TPL and DSPC of asthma group were statistically lower than normal control group P 0.01.In contrast, the levels of TP of asthma group were obviously higher as compared with it P 0.01.The levels of DSPC/TP,DSPC/TPL and DSPC of ambroxol treaded groups, small and large ambroxol treated group , which were similar to each other on DSPC/TP,DSPC/TPL,DSPC and TP( P 0.05),were statistically higher than asthma group( P 0.01), the levels of TP of them were obviously lower compared with asthma group P 0.01.Conclusions Ambroxol can promote in synthesize and secretion of PS .Small dose ambroxol can play a role as good as large dose ambroxol.
【CateGory Index】: R562.25
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