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《Journal of Chinese Physician》 2004-05
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Selection of the Formula of the 0.5% Liposome Podophyllotoxin Chitosan Film

ZHU Xiao-liang,ZENG Kang,ZHANG San-quan,et al. Department of Dermatology, Nanfang Hospital of The First Military Medical University, Guangzhou 510515, China  
Objective To explore the best formula of the 0 5% liposome podophyllotoxin chitosan film. Methods Chitosan,acetic acid and gelatin were selected as three factors to prepare film, each factor including three levels, and 0 5% liposome podophyllotoxin served as blank factor. The films of different formula were prepared according to orthogonal design. The evaluation was made on the basis of the characteristics of conglutination and dissolution, then the best formula was determined finally. Results The results showed that the conglutination and dissolution of the film which was made of 2% chitosan, 1%acetic acid, 2% gelatin and 0 5% liposome podophyllotoxin chitosan was the most perfect. Conclusion The film designed according to orthogonal experiment was coincidenced with the requirements in aspect of conglutination and dissolution, and its appearance was perfect.
【Fund】: 广东省重点科技攻关计划基金资助 (C1 1 70 4 )
【CateGory Index】: R943
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