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《Journal of Chinese Physician》 2005-03
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The Effect of Human Placenta Lipopolysaccharide and Dexamethasone on Spontaneous Resorption of Herniated Intervertebral Disc

CHEN Fei,LI Kang-hua,LU Guo-hua. Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha 410011, China  
Objective To explore the effect of human placenta lipopolysaccharide (LPS) and dexamethasone (DXM) on spontaneous resorption of herniated intervertebral disc. Methods The animal model of intervertebral disc herniation was set up by placing the harvested disc into the epidural space at L4 or L5 of the same rahbit. Then the 24 rabbits were randomly divided into three groups. In human placenta LPS group, rabbits were intraperitoneally injected 2ml of human placenta LPS at the second, 6th and 10th days after surgery. In DXM group, rahbits were intravenously injected 1mg/kg of DXM at the second to 15th days after surgery. In control group, rubbits were intravenously injected 3ml/kg of normal saline at the second to 15th days after surgery. All rahbits were killed, and herniated intervertebral disc was removed for histological and immunohisto- chemical examination at the 12th weeks after surgery. Results A great amount of newly formed vessles and inflammation cells were founded in the disc tissues in the LPS group. In the control group, a lot of granular tissues were founded in the disc tissues. In the DXM group, small amount of granular tissues were founded in the disc tissues. The expression levels of bFGF, CD68 and VEGF in the LPS group were significantly higher than those in the control group (P0.05). The expression levels of bFGF, CD68 and VEGF were significantly higher in the control group than those in the DXM group (P0.05). There was significant difference in MVD between the control group and DXM group(P0.05), and between the LPS group and control group. Conclusion Autologous intervertebral disc grafted into the epidural space was penetrated by newly formed vessels and macrophages, and resolved as the result of inflammatory reaction. Human placenta LPS could accelerate the spontaneous resorption of herniated intervertebral disc by upregulating VEGF, bFGF expression and angiogenesis, whereas DXM could inhibit the resportion of herniated intervertebral disc by downregulating the expression of VEGF and bFGF.
【CateGory Index】: R681.5
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【References】
China Proceedings of conference Full-text Database 1 Hits
1 KANG Jian-nan YAN Qi-quan KANG Hui-ran ZHOU Hai-bo (Hunan Yige Pharmaceutical Co.,Ltd.,Xiangtan 411100,China);Study on the production process of human placenta lipopolysaccharide[A];[C];2008
【Citations】
Chinese Journal Full-text Database 1 Hits
1 HU Chun-ling*, YU Lun-yin, CHEN De-ji, LIU Ming-qiu,JIANG Man,TANG Zhi-jiao, XIA Dong,LIU Xuan,CHEN Hong-lei,LI Hong-gang Department of Pathology, Medical College, Wuhan University, Wuhan 430071, P.R.China;Changes of VEGF,FLK-1 Expressions and Vasculature during Lung Carcinogenesis Induced by 3-Methylcholanthrene and Diethyinitrosamine in Wistar Rats[J];Chinese Journal of Cancer;2001-07
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 LI Hong gang*, YU Lun yin, LIU Ming qiu, CHEN Hong lei, ZHANG Yu xia,LIU Xuan, TANG Zhi jiao, XIA Dong, ZOU Zu yuDepartment of Pathology,Medical College of Wuhan University,Wuhan 430071,P.R.China;A Study on Cyclooxygenase-2 Protein Expression and Vasculature during Experimental Rat Lung Carcinogenesis[J];Chinese Journal of Cancer;2002-06
2 XIANG Feng-gang, MA Gui-xin (Department of Pathology, Qingdao University Medical College, Qingdao 266021, China);;EXPRESSION OF VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTORS Flt1 AND KDR IN PULMONARY CARCINOMA AND THEIR RELATIONSHIP WITH METASTASIS AND PROGNOSIS[J];Acta Acadimae Qingdao Umvesitatis;2004-01
3 LIANG Gang, ZHONG De-wu, YANG Zhu-lin, et al. Department of Hepatobilliary Surgery, Hunan Provincial People's Hospital, Changsha 410002, China;The Expression of hMLH_1, hMSH_2 in Hepatocellular Carcinoma and Its Clinical Significance[J];Journal of Chinese Physician;2005-06
4 YANG Han-Zheng1, WU Jian-Cheng2,CHENG Yu-Sheng1, SHI Wei-Hong11Department of Immunology,Yancheng Health Vocational and Technical College,Yancheng 224001,China,2Department of Infection,First Hospital,Suzhou University,Suzhou 215006,China;Expression of interleukin-18 binding protein in chronic hepatitis and hepatic carcinoma and its significance[J];Journal of the Fourth Military Medical University;2008-21
5 LI Honggang, CHEN Fuchun, LIU Mingqiu, ZHU Liqin, FAN Lifang, CHEN Honglei. Tongji Medical College, Huazhong Science University, Wuhan, Hubei 430030, P.R.China;Cyclooxygenase-2, inducible nitric oxide synthase protein expression and vasculature during experimental rat lung carcinogenesis[J];Chinese Journal of Lung Cancer;2003-02
6 LIU Xiang-feng~*,ZHONG De-wu~*,WU Jin-shu,et al.* Department of Hepatobiliary Surgery,the Second Xiangya Hospital of Central South Universtiy,Changsha 410001;Expression of EMMPRIN,TIMP-2,MMP-1 in gallbladder carcinoma tissues of human and its correlation with microvessel count[J];Journal of Hepatopancreatobiliary Surgery;2005-04
7 LIU Xiang-feng,ZHONG De-wu,YANG Zhu-lin.Department of General Surgery,the Second Xiangya Hospital of Central South University,Changsha 410002;Relationship between the expression of survivin and microvessel density in primary hepatic carcinoma tissues[J];Journal of Hepatopancreatobiliary Surgery;2006-06
8 YANG Leping,YANG Zhulin,DENG Xinghui,et al.Research Lab of Hepatobiliary Diseases,the Xiangya Second Hospital of Centrosouthern University,Changsha 410011;Establishment of a model for pancreatic cancer in Sprague-Dawely(SD) rat and study on the relationship among IL-8,MCP-1,MIP-1α mRNA and MC count in the rat pancreatic cancer[J];Journal of Hepatopancreatobiliary Surgery;2007-01
9 HUANG Sheng fu *,YANG Zhu lin,DENG Xing hui,MIAO Xiong ying,ZHUANG Zan geng,LI Yong guo(Research Laboratory of Hepatobiliary Diseases,Second Xiangya Hospital,Central South University, Changsha 410011,China);Correlative study on the expression of ER mRNA and presenilin 2in the pancreatic carcinoma tissues[J];;2004-04
10 HUANG Sheng-fu, YANG Zhu-lin, DENG Xing-hui,et al(Research Laboratory of Hepatobiliary Diseases, The Second Affiliated Xiangya Hospital of Central South University, Changsha 410011, Hunan,China);Expression of EMMPRIN, MMP_1, MMP_9 and TIMP_1 in Pancreatic Carcinoma and Chronic Pancreatitis and Its Clinicopathological Significance[J];Journal of Elinical Research;2004-06
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 WANG Huai-Cheng- HAN Qing (Department of Pulmonology- the third people's hospital- Changzhou- Jiangsu- 213001- China);Clinical effects and cytokine of Human Placenta Lipopolysaccharide assisted method in treatment of new smear-positive tuberculosis patients[J];Hainan Medical Journal;2006-07
2 GONG Liang-tai,XU Fu-yu,SONG Ruo-xian,et al(Dept.of Orthopaedics,Qilu Hospital of Shandong University);Significance of immunoreaction in spontaneous absorption of the experimental free herniated nucleus pulposus[J];Acta Academiae Medicinae Shandong;2002-06
3 Li Jun, Liu miao,Zhu Liping (Department of Orthopaedic Surgery, First Affiliated Hospital);A STUDY ON THE RELATIONSHIP BETWEEN THE PATHOLOGICAL CLASSIFICATIONS OF LUMBAR DISC HERNIATION AND LOCAL & GENERAL HUMORAL IMMUNE STATUS[J];JOURNAL OF XI'AN MEDICAL UNIVERSITY(CHINESE);1999-03
4 SONG Ruo-xian,GONG liang-tai,XU Fu-yu,et al.Ji' nan General Hospital of PLA ,Ji' nan 250031,China;Distribution of IgG and the possible mechanism in spontaneous resorption of the herniated nucleus pulposus in a dog model[J];Modern Rehabilitation;2002-22
5 Ruo Xian Song,Liang Tai Gong,Fu Yu Xu,Zhen Yuan Ruo Xian Song,Department of Orthopaedics,General Hospital of Jinan Command,Jinan 250031,Shandong Province,China Liang Tai Gong,Department of Orthopaedics,Qilu Hospital,Shandong University,Jinan 250014,Shandong Province,China Fu Yu Xu,Department of Pathology,Qilu Hospital,Shandong University,Jinan 250014,Shandong Province,China Zhen Yuan,Department of Orthopaedics,Qianfoshan Hospital of Shandong Province,Jinan 250016,Shandong Province,China;Possible mechanism in spontaneous resorption or contracion of the herniated nucleus pulposus[J];Chinese Journal of Clinical Rehabilitation;2004-08
6 Gao Lingyun, Cui Huiyun, Tian Zhuang,et al The Forth Hospital Bao Tou City,Aluminum Plant Hospital Bao Tou CityBao Tou Inner Mongolia 014030;Research on Internal Absorption and Related Factors After Protrasion of Intervertebral Disc in Lumbar[J];Chinese Journal of Traditional Medical Traumatology & Orthopedics;2004-05
7 LI Jing  ,ZHOU Jiangnan,LI Kanghua,et al.  Department of Spinal Surgery,the Second Xiangya Hospital,Central Sout h University,Changsha 410011,China;The study of the mechanism of resorpt ion of herniated disc tissue[J];Chinese Journal of Orthopaedics;2002-06
8 CHEN Qi-xin, LIU Yao-sheng, LI Fang-cai, et al. The 2nd Hospital of Medical College, Zhejiang University, Hangzhou 310009, China;Histopathological changes of sequestration-type lumbar herniated disc[J];Chinese Journal of Orthopaedics;2006-08
9 WU Jing-ping *,CHEN Tong-yi,CHEN Zhong-wei,et al. *Department of Orthopedics,Jinshan Hospital,Fudan University,Shanghai 200540,China;The development of a degenerative disc animal model in bipedal rats[J];Chinese Journal of Experimental Surgery;2004-01
10 YANG Sheng, SHI Ke zhong, AN Rong ze,et al. Departement of Orthopaedics, The First Affiliated Hospital, Zunyi Medical College, Zunyi 563003;In Expression of Matrix Metalloproteinase-3 in Intervertebral Disc Herniation[J];The Orthopedic Journal of China;2000-11
【Secondary References】
Chinese Journal Full-text Database 3 Hits
1 Liu-Jintao,JiangHong,WangYongjun,et al.Suzhou Hospital of TCM Jiangsu,215003;A Rat Model of Disc Herniation Spontaneous Resorption[J];Chinese Journal of Bone and Joint Injury;2009-11
2 JIANG Hong,LIU Jin-tao,HUI Ren-ghua,et al. (1.Department of Orthopedics,CTM Hospital of Suzhou,215003;2.Institue of Spinal Disease,University of CTM Shanghai,China,201203. );The study of autoimmune response in the ressorption of ruptured disc herniation animal model[J];The Journal of Cervicodynia and Lumbodynia;2009-01
3 LI Xing-liang1,XU Hua-ming2,LIU Jin-tao2(1.College of Electronics and Information Engineering,Suzhou University of Science and Technology,Suzhou 215011,China;2.Suzhou Traditional Chinese Medicine Hosptial,Suzhou 215003,China);New Algorithm for MR Image Segmentation of the Lumbar Intervertebral Disc Protrusion[J];Journal of Jiangnan University(Natural Science Edition);2009-05
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 Liu Ming- qiu,Yu Lun- yin,Shu Qing- bo,et al Hubei Medical University,Wuhan 430071;EFFECT OF SUPEROXIDE DISMUTASE AND DIETHYLDITHIOCARBAMATE ON THE INDUCTION OF SQUAMOUS CELL CARCINOMA OF LUNG WITH METHYLCHOLANTHRENE IN RATS[J];CHINESE JOURNAL OF ONCOLOGY;1994-04
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