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《Journal of Chinese Physician》 2005-03
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The Effect of Human Placenta Lipopolysaccharide and Dexamethasone on Spontaneous Resorption of Herniated Intervertebral Disc

CHEN Fei,LI Kang-hua,LU Guo-hua. Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha 410011, China  
Objective To explore the effect of human placenta lipopolysaccharide (LPS) and dexamethasone (DXM) on spontaneous resorption of herniated intervertebral disc. Methods The animal model of intervertebral disc herniation was set up by placing the harvested disc into the epidural space at L4 or L5 of the same rahbit. Then the 24 rabbits were randomly divided into three groups. In human placenta LPS group, rabbits were intraperitoneally injected 2ml of human placenta LPS at the second, 6th and 10th days after surgery. In DXM group, rahbits were intravenously injected 1mg/kg of DXM at the second to 15th days after surgery. In control group, rubbits were intravenously injected 3ml/kg of normal saline at the second to 15th days after surgery. All rahbits were killed, and herniated intervertebral disc was removed for histological and immunohisto- chemical examination at the 12th weeks after surgery. Results A great amount of newly formed vessles and inflammation cells were founded in the disc tissues in the LPS group. In the control group, a lot of granular tissues were founded in the disc tissues. In the DXM group, small amount of granular tissues were founded in the disc tissues. The expression levels of bFGF, CD68 and VEGF in the LPS group were significantly higher than those in the control group (P0.05). The expression levels of bFGF, CD68 and VEGF were significantly higher in the control group than those in the DXM group (P0.05). There was significant difference in MVD between the control group and DXM group(P0.05), and between the LPS group and control group. Conclusion Autologous intervertebral disc grafted into the epidural space was penetrated by newly formed vessels and macrophages, and resolved as the result of inflammatory reaction. Human placenta LPS could accelerate the spontaneous resorption of herniated intervertebral disc by upregulating VEGF, bFGF expression and angiogenesis, whereas DXM could inhibit the resportion of herniated intervertebral disc by downregulating the expression of VEGF and bFGF.
【CateGory Index】: R681.5
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