Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Chinese Physician》 2005-05
Add to Favorite Get Latest Update

The Effect of Levo-anlodipine on Myocardial Cells Calcium Overload in Anoxic Condition

LONG Kai-chao, LI Tong, XIAO Chang-jiang,et al. Department of Cardiology, Xiangya Hospital,Central South University, Changsha 410008, China  
Objective To observe the protective effect of levo-anlodipine on the calcium overload in the anoxic myocardial cells. Methods Myocardial cells were cultured, and in vitro model of anoxic myocardial cells was established. Fura2/am fluorescent probe was used to measure the free calcium concentration of the myocardial cells by spectrofluorometer. The expression of Ca~2+ ATPase of cellular membrane was detected by RT-PCR, and the content of calcium pump in sarcoplasmic reticulum was measured by western blot. Results The levo-anlodipine could decrease the free calcium concentration of the anoxic myocardial cells markedly(359.06±75.00nM), and increase the expression of Ca~2+ ATPase of cellular membrane and the content of calcium pump of sarcoplasmic reticulum in the anoxic myocardial cells. Conclusion Levo-anlodipine could enhance the resistance to calcium overload in anoxic myocardial cells through increasing the expression of Ca~2+ ATPase.
【CateGory Index】: R965
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 3 Hits
1 Chen Hongqin1,et al Department of Cardiovasology,Southwest Hospital;THE EFFECTS OF HYPOXIA ON L-TYPE Ca~(2+) CHANNEL OF CARDIAC MYOCYTE IN RATS[J];Journal of High Altitude Medicine;2001-02
2 Peng Zhanglong,Hang Yannan,Sun Dajin Department of Anesthesiology,Renji Hospital,Shanghai Second Medical University,Shanghai 200001;Effect of Nicardipine on Anoxia Reoxygenation Injury and Intracellular Calcium in Primary Culture Myocardial Cells[J];THE JOURNAL OF CLINICAL ANESTHESILOLGY;2000-07
3 Li Zipu, Liu Yuyang, Gu Juanhong,et al(Department of Pedialrics, Children's Hospital, Shanghai Medical University;Shanghai 200032);The influence of calcium antagonist used prophylactically on myocyte and erythrocyte calcium in ischemic rat[J];SHANGHAI MEDICAL JOURNAL;1997-05
Chinese Journal Full-text Database 10 Hits
1 MA Gui-xi1,LI Ming-gao1,HAN Lei1,MEN Guo1,LIU Yu1,LI Jing1,HUANG You-zhang2(1.Department of Aviation and Driving Medicine,Naval General Hospital,Bejing 100037,China;2.Department of Hematology,Naval General Hospital,Bejing 100037,China);Effects of Diltiazem on Intracellular Mitochondria Membrance Potential of Human Vascular Endothelial Cells under Hypoxia[J];Journal of Naval General Hospital;2007-03
2 LIU Sui-Xin, SUN Ming, and LI Tong (Department of Cardiac Rehibilitation Centre, Xiangya Hospital, Central South University, Changsha 410008, China);Effects of Levo-Anlodipine on Lactate Dehydrogenase and Cardiac Troponin of the Anoxic Myocardial Cells[J];Chinese Journal of Arterial Lerosis;2005-01
3 ZHAO Tong-zhou,et al.(The people's Hospital of Guyuan,Guyuan 756000,China);The effects of dioscornin on cerebral blood flow of the patients with diabetes and arteriosclerosis of carotid artery[J];Ningxia Medical Journal;2008-02
4 MA Gui-xi,LI Ming-gao,HAN Lei,LIU Yu,LI Jing,HUANG You-zhang(Aviation and Diving Medical Center,Navy Gene-ral Hospital,Beijing 100037,China;);Diltiazem attenuates the changes of mitochondria membrane potential induced by hypoxia in human vascular endothelial cells[J];Journal of Shanxi Medical University;2008-04
5 HUANG Jian-xin1,LI Hua-feng2,WANG Quan-yun1.1.West China Hospital,Sichuan University,Chengdu,Sichuan 610041;2.West China Second Hospital,Sichuan University,Chegndu,Sichuan 610041,China;The influence of fentanyl on the anoxic reoxygenation injury of the neonatal rat cardiomyocytes[J];Sichuan Medical Journal;2009-10
6 ZHAO Yan-peng(The People's Hospital of Guyuan,Guyuan 756000,Ningxia,China);Effect of Weiaoxin on brain hemodynamics in patients with carotid artery atherosclerosis[J];Modern Journal of Integrated Traditional Chinese and Western Medicine;2007-34
7 XU Da-qing,LEI Jie,PENG Xiao-dong,et al (Dept.of Pharmacy,the Affiliated Second Hospital Ningxia Med.Coll.,Yinchuan 750001);The Protective Effect of Daidzein on Cardiomyocytes of Neonatal Rats Injuried by Anoxia/Reoxygenation[J];Journal of Ningxia Medical College;2007-04
8 LIU Sui-xin, LI Tong, SUN Ming (Center of Cardiac Rehabilitation, Xiangya Hospital, Central South University, Changsha HU-NAN 410008, China);Effect of l-amlodipine on calcium signaling system in anoxic myocardial cells[J];Chinese Journal of New Drugs and Clinical Remedies;2005-04
9 ZHAO Zheng Hang, ZANG Wei Jin, YU Xiao Jiang, SUN Qiang, LU Jun, ZHANG Chun Ηong (Dept of Pharmacology, School of Medicine, Xi'an Jiaotong University, Xi'an 710061);Effects of adenosine on action potential and its ionic mechanisms in guinea-pig ventricular myocytes under simulated ischemic-reperfused conditions[J];Chinese Pharmacological Bulletin;2003-03
10 HUANG Jian-xin,WANG Quan-yun( Department of Anesthia,Sichuan Provincial People's Hospital,Chengde 610072,China);The comparison of fentanyl and anoxic preconditioning on the anoxic reoxygenation injury of the neonatal rat cardiomyocytes[J];Practical Journal of Clinical Medicine;2009-04
Chinese Journal Full-text Database 10 Hits
1 ZHANG Jun-Wen1, WANG Pi-Long1, YANG Zhi-Bang2 1. Department of Gastroenterology, The First Affiliated Hospital, Chongqing University Medical Sciences, Chongqing, 400016, P. R. China 2. Department of Microbiology, Chongqing University Medical Sciences, Chongqing, 400016, P. R. China;Establishment of Cellular Hypoxia Model and Its Effects on Biological Behavior of Gastric Cancer Cell Line SGC-7901[J];Chinese Journal of Cancer;2005-10
2 GAO Wei,JIANG Xiu-Fang,FAN Chun-mei,ZHENG Ju-hua,WANG Dan(Medical College,Dalian University,Dalian 116622,China);Study on effects of anti-anoxia of baikal skullcap root[J];Journal of Dalian University;2006-02
3 Wang Yi,Niu Wenzhong,Zhang Jinjun 1,Wang Hongjun,Chen Ninrong Department of High Altitude Medicine of Chengdu Military Command;EFFECT OF NEW TIBETAN MEDICINE ON HYPOXIA OF RECRUITS EXPOSED RAPIDLY TO HIGH ALTITUDE[J];Journal of High Altitude Medicine;2003-02
4 LIN Songyi~(1,2), YIN Yongguang~1,LIU Jingbo~1,CHENG Sheng~3(1.College of Biological and Agricultural Engineering, Jilin University,Changchun 130022,China;2.Biological and Food Engineering Department, Jilin Teachers' Institute ofn-machine Bionics Engineering, Ministry of Education, Jilin University, Changchun 130022, China);Anti-anoxic effects for mice of functional liquid from Chinesetraditional compound medicines[J];Journal of Jilin University of Technology(Natural Science Edition);2005-01
6 REN Li1,YU Hong-ru2,WANG Hong-xin2(1.Department of Biochemistry,Liaoning Medical University;2.Jinzhou Ahon Pharmaceuticals Co.LTD.,Jinzhou 121000 China);Comparison of Hypoxic Effects of Several Models of in-vitro Cultured Neurons[J];Journal of Liaoning Medical University;2007-01
7 Yang Mei, Kou Yiying,Li Yongfang, et al. Qinghai University Medical College;THE PRELIMINARY STUDY OF THE EFFECTS OF SANWEITANXIANG POWDER ON HYPOXIA AND MYOCARDIAL ISCHEMIA IN ANIMAL MODEL[J];Journal of Qinghai Medical College;2005-04
8 WANG Ya-qin,Tan Zhi-wei,GUAN Peng,et al.(Department of Forensic Pathology,West China School of Preclinical and Forensic Medicine,Sichuan University,Chengdu 610041,China);Establishment of neurons glucose oxygen deprivation mode in vitro and the cellular injuries[J];Sichuan Journal of Anatomy;2007-01
9 Tian YH, Li SJ, Li XW, Gao TM 1Department of Physiology, 2Department of Neurobiology, School of Basic Medical Science, Southern Medical University, Guangzhou 510515, Guangdong Province, China;Improvement in the preparation of hypoxia/reperfusion models of rat hippocampal neurons in vitro[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2007-15
10 Zeng Ren-jie 1, JING Li 1, SHUN Wei-zhang 1, WANG Qiu 2. 1 Dep artment of Pharmacology, General Hospital of Chengdu Military Command, Chengdu 6 10083. 2.Department of Pharmacology, Guiyang Medical College.;Contrast study on the anti-hypoxia effect of Rhodiolae oral liquor and compound Danshen drop pills[J];Medicial Journal of National Defending Forces in Southwest China;2004-01
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 Liu Gongxin Gu Quanbaro Guo Qi Yan Yinzhen Shanghai Medical University, Shanghai 200032; 1Shanghai Institute of Cardiovascular Diseases);A SIMPLE,RAPID METHOD TO ISOLATE CARDIAC MYOCYTES FROM RAT AND GUINEA PIG[J];CHINESE JOURNAL OF APPLIED PHYSIOLOGY;1997-04
2 Nong Shaohan;Li Zhuosuan;Feng Zekang;et al. (Department of Pediatrics,BuangdongProvincial People's Hospital,Guangzhou510080.);CHANGES OF INTRA- AND EXTRA-CEL-LULAR CALCIUM CONCENTRATIONS IN BRAIN CELLS AND ERYTHROCYTES PRI-OR TO AND POST CALCIUM SUPPLEMEN-TATION IN NEONATAL RAT HYPOXIC IS-CHEMIC ENCEPHALOPATHY MODEL[J];Chinexe Journal of Pediatrics;1995-06
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved