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《Journal of Chinese Physician》 2005-07
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Relationship between the Th1/Th2 Cytokines Imbalance and Autoimmune Thyroid Diseases

TANG Ya-mei, CHEN Zhi-heng, TANG Ai-guo. Department of Clinical Laboratory, The Second Xiangya Hospital, Central South University, Changsha 410011, China  
Objective To analyze the relationship between serum Th1/Th2 cytokines levels and autoantibodies against thyroid, and explore the role of Th1/Th2 cellular immunity imbalance in the pathogenesis of autoimmune thyroid diseases(AITD). Methods 21 patients with Graves'desease(GD), 18 cases with Hashimoto's thyroiditis(HT), 17 cases with non-toxic nodular goiter(NTNG) and 20 healthy subjects were enrolled in this study. The serum concentrations of their Th1 cytokines (IFN-γ,IL-2) and Th2 cytokines (IL-4,IL-10) were assayed by ELISA. The serum levels of their thyrotropin receptor antibodies(TRAb), thyroglobulin antibodies (TGAb) and thyroid peroxidase antibodies(TPOAb) were measured by routine methods. The relationship between the serum Th1, Th2 cytokines levels and serum TRAb, TGAb, TPOAb levels were analyzed. Results The serum levels of IL-4 and IL-10 in patients with GD were significantly higher than those in patients with HT,NTNG and healthy subjects(P0.01), while the serum levels of INF-γ and IL-2 in patients with HT were significantly higher than those in patients with GD,NTNG and healthy subjects(P0.01), and serum IL-4 level was significantly lower than that in healthy subject as well (P0.05). In GD patients, the serum levels of both IL-4 and IL-10 were positively associated with serum TRAb titer, respectively(r=0.683, 0.579;P0.05). In HT patients, the serum levels of both IFN-γ and IL-2 were positively associated with serum TGAb and TPOAb titers, respectively (IFN-γ:r=0.542, 0.650;IL-2:r=0.517,0.602;P0.05). Conclusion The patients with GD or HT had a cellular immunity imbalance, a Th2 cell immune response was dominant in GD patients, whereas a Th1 cell immune response was dominant in HT patients.
【CateGory Index】: R581
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