Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Chinese Physician》 2005-07
Add to Favorite Get Latest Update

Relationship between the Th1/Th2 Cytokines Imbalance and Autoimmune Thyroid Diseases

TANG Ya-mei, CHEN Zhi-heng, TANG Ai-guo. Department of Clinical Laboratory, The Second Xiangya Hospital, Central South University, Changsha 410011, China  
Objective To analyze the relationship between serum Th1/Th2 cytokines levels and autoantibodies against thyroid, and explore the role of Th1/Th2 cellular immunity imbalance in the pathogenesis of autoimmune thyroid diseases(AITD). Methods 21 patients with Graves'desease(GD), 18 cases with Hashimoto's thyroiditis(HT), 17 cases with non-toxic nodular goiter(NTNG) and 20 healthy subjects were enrolled in this study. The serum concentrations of their Th1 cytokines (IFN-γ,IL-2) and Th2 cytokines (IL-4,IL-10) were assayed by ELISA. The serum levels of their thyrotropin receptor antibodies(TRAb), thyroglobulin antibodies (TGAb) and thyroid peroxidase antibodies(TPOAb) were measured by routine methods. The relationship between the serum Th1, Th2 cytokines levels and serum TRAb, TGAb, TPOAb levels were analyzed. Results The serum levels of IL-4 and IL-10 in patients with GD were significantly higher than those in patients with HT,NTNG and healthy subjects(P0.01), while the serum levels of INF-γ and IL-2 in patients with HT were significantly higher than those in patients with GD,NTNG and healthy subjects(P0.01), and serum IL-4 level was significantly lower than that in healthy subject as well (P0.05). In GD patients, the serum levels of both IL-4 and IL-10 were positively associated with serum TRAb titer, respectively(r=0.683, 0.579;P0.05). In HT patients, the serum levels of both IFN-γ and IL-2 were positively associated with serum TGAb and TPOAb titers, respectively (IFN-γ:r=0.542, 0.650;IL-2:r=0.517,0.602;P0.05). Conclusion The patients with GD or HT had a cellular immunity imbalance, a Th2 cell immune response was dominant in GD patients, whereas a Th1 cell immune response was dominant in HT patients.
【CateGory Index】: R581
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 4 Hits
1 FENG Xue-min,QIN Ming-xiu,ZHAO Yan(Department of Nuclear Medicine,First Central Hospital of Tianjin,Tianjin 300192,China);The Diagnostic Value of Th1/Th2 Cell Cytokine and Thyroid Autoantibody on Autoimmune Thyroid Diseases[J];Labeled Immunoassays and Clinical Medicine;2008-04
2 MA Qing-he1,LIU Rong-xin1,CHEN Bin1,WANG Shi-zhe2,LI Hai-yan2,JIANG Guo-jun1 (1.College of Traditional Chinese Veterinary Medicine,Hebei Agricultural University,Dingzhou,Hebei,073000,China;2.Agricultural and Animal Husbandry Bureau of Dingzhou County,Dingzhou,Hebei,073000,China);Detection of Levelsin of IL-2 in the Placenta of Cows with Placenta Retention[J];Progress in Veterinary Medicine;2010-08
3 YANG Yu,XIE Li-ling,KE Jiang-wei,YANG Li(Department of Endocrinology,Jiangxi Children′s Hospital,Nanchang 330006,China);Cytokine Imbalance and Its Function in Morbidity of Autoimmune Thyroid Disease in Children[J];Journal of Applied Clinical Pediatrics;2007-20
4 YE Ting-jun,MAO Min-jing,FAN Qi-shi,SHI Xin-ming Department of Clinical Laboratory,Ruijin Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200025,China;Relation between interleukin-2,interleukin-2 receptor and thyroid peroxidase antibodies in Hashimoto’s thyroiditis[J];Journal of Diagnostics Concepts & Practice;2008-02
Chinese Journal Full-text Database 10 Hits
1 GE Dai-chu1,LIU Wei2(1.The Professional Hospital of China Coal the Third Reeonstraction,Anhui Suzhou 234000;2.The First Affiliated Hospital of Anhui Medical University,Anhui Hefei 230022);Significance of tests of thyroid autoantibodies in differential diagnosis between Hashimoto′s hyperthyroidism and Graves' disease[J];Anhui Medical and Pharmaceutical Journal;2007-06
2 ZHANG Rong-Xin1,ZHU Jin-Hai1,SONG Huai-Dong2(1.Department of Tumour Surgery,The First Affiliated Hospital of Bengbu Medical College,Bengbu 233004;2.The Center of Molecular Medicine,Ruijin Hospital Affiliated of Shanghai Jiaotong University Medical School,Shanghai 200025,China);Uteroglobin-related protein 1 expression in thyroid diseases and its clinical significance[J];Journal of Bengbu Medical College;2007-05
3 Sun Yu, Lin Jiexin,Wang Huijun Medical School of Zhejiang Ocean University,Zhoushan (316004);Changes of Serum IL-12,TNF-α Levels before and after Treatment and It’s Clinical Meanings in Graves Disease[J];;2006-01
4 FENG Kun,YANG Yu-zhi,LI Xian-hou,et al.(Department of Endocrinology,Heilongjiang Prorince Hospital,Haerbin 150036,China);Expression of IL-10,TNF-α mRNA in TEC in Graves′ Disease[J];Labeled Immunoassays and Clinical Medicine;2003-02
5 ZHU Ming-feng,WEN Chi-jun,QIAN Hong(Department of Nuclear Medicine,The Second People's Hospital of Shanghai,Shanghai 200011,China);Relationship Between Prognosis of Graves' Disease Treated with ~(131)I and Three Kinds of Cell Factors[J];Labeled Immunoassays and Clinical Medicine;2007-03
6 FENG Xue-min,QIN Ming-xiu,ZHAO Yan(Department of Nuclear Medicine,First Central Hospital of Tianjin,Tianjin 300192,China);The Diagnostic Value of Th1/Th2 Cell Cytokine and Thyroid Autoantibody on Autoimmune Thyroid Diseases[J];Labeled Immunoassays and Clinical Medicine;2008-04
7 LIU Yan wei1, DEN Ze pei2; ZHOU Zhan xiang2(1.Department of Animal Science and Veterinary Medicine, Handan Agricultural School, Handan, Hebei 057150, China;2. College of Veterinary Medicine Science, China Agricultural University, Beijing 100094, China);Fluctuating Regulation of Plasma PGE2 Plane in Cow with Retention of Fetal Membrane[J];Journal of Yellow Cattle Science;2001-04
8 Pang Shuguang 1,Sun Guojian 2,Sun Jinfeng 1 (Central Hospital of Jinan,Jinan 250013);THE DETERMINATION OF SERUM TNFα IN PATIENTS WITH GRAVES DISEASE AND ITS CLINICAL SIGNIFICANCE[J];Journal of Binzhou Medical College;2004-02
9 WANG Ai-hua,YAN Hua (Tird Hospital of Tangshan,Hebei Tangsha 063100,China);STUDY OF THE CYTOKINES OF TNF-α AND IL-10 IN THE DECIDUA AND CHORION IN SPONTANEOUS ABORTION[J];Journal of Chengde Medical College;2002-03
10 FENG Ying kai,XU Jian cheng,YANG Qing hua,et al. (1.Institute of Respiratory Disease of P.L.A,Xinqiao Hospital,the Third Military Medical University,Chongqing 400037,China;2.Medical Information Center of Chongqing,Chongqing 400014,China);Apoptosis of CD4~+T cells and its effects in lipopolysaccharide-induced acute lung injury in rats[J];Chongqing Medical Journal;2004-01
【Secondary References】
Chinese Journal Full-text Database 4 Hits
1 LI Qi-zhang,WANG Xue-fei,HUANG Lei,ZHOU Xuan-wei*(Plant Biotechnology Research Center,School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai 200240,China);Fungal Immunomodulatory Protein from Ganoderma sinense Expressed in E.coli and the Identification of Immunocompetence[J];Acta Botanica Boreali-Occidentalia Sinica;2010-01
2 LI Yan,LI Qiang,MAIREMU (Hutubi Herd Farm in Xinjiang,Hutubi Xinjiang 831200,China);Research on Retention of Afterbirth in Holstein Cows[J];Grass-Feeding Livestock;2011-03
3 LV Jian-cun,LIU Rong-xin(College of Traditional Chinese Veterinary Medicine,Hebei Agricultural University,Dingzhou 073000,China);Effect of combined use of Jiaweisijunzisan and Yimushenghuasan on the contents of IL-2,IFN-γ and TNF-α in the plasma of peripartum dairy cows[J];Chinese Journal of Veterinary Medicine;2011-06
4 LU Jie,ZHANG Dong-chu,XIA Shu-qi,ZHANG De-ting,TONG Yu(Wenzhou Third People′s Hospital,Wenzhou 325000,China);The significance of CD4~+CD28~-and CD8~+CD28~-T cells′ expressions in patients with hashimoto′s thyroiditis[J];Chinese Journal of Health Laboratory Technology;2011-10
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved