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《Journal of Chinese Physician》 2006-10
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Effects of Astraglus on renal injury of diabetic rats

CHENG Hui,JIA Ru-han,LIU Hong-yan.Renmin Hospital of Wuhan University,Wuhan 430060,China  
Objective To investigate the role of Astragalus for renal protection in diabetic rats.Methods 30 wistar rats were divided into three groups: ⑴normal controls(group A),⑵diabetic rats(group B),⑶diabetic rats + Astragalus injection at 6th week after initiating DM(group C).The rats were sacrificed at the end of the 8th week.The levels of renal cortex T-SOD,GSH-Px,MDA,NO_2~-/NO_3~-and NOS were analyzed.Results From the end of the 1st week,Ccr and UAE were increased significantly in group B and C compared to group A(P0.01).At the 8th week, renal cortex T-SOD and GSH-Px were increased and MDA was decreased significantly in group C compared to those in group B(P0.01).Renal cortex NO_2~-/NO_3~-and NOS were significantly increased in group C compared to group B(P0.01).There was no obvious difference between group A and group C.The animals in group C showed less pathological alterations under light microscope,less PAS positive materials and less CollagensⅣ depositions than those in group B.Conclusion Astragalus can relieve the renal tissue lipid peroxidantion by improving the activity of SOD and GSH-Px.It can also clear up ROS and increase the synthesis of NO.Addition of Astragalus in the development of DN can extenuate masangial matrix expansion and may delay the process of glomeruloscherosis.
【CateGory Index】: R285
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