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《ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY》 1999-10
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Oxymatrine downregulate HBV gene expression in HBV transgenic mice

Chen Xiaosong, Wang Guojun, Cai Xiong, Yu Hongyu, Hu Yiping (Department of Infectious Disease,Changzheng Hospital, Second Military Medical University, Shanghai, 200003)  
Objective: To explore the effect of oxymatrine (Oxy) on HBV. Methods: HBV transgenic mice ICR TgN (HBV adr 1.2)SMMU was used in this study. ELISA and immunohistochemistry methods were adopted to determine the expression level of HBV in liver of transgenic mice. Results: Injected with Oxy 100, 200 or 300 mg/kg intraperitonealy once a day for 30 days later, HBV transgenic mice showed lower HBV gene product content in liver than control (injected with saline for 30 days). Further study indicated that Oxy can downregulate HBV gene expression when injected 200 mg/kg for 10 and 20 days. Conclusion: Oxy can decrease the content of HBsAg and HBcAg in HBV transgenic mice liver at the same time.
【Fund】: 上海市科技启明星计划资助
【CateGory Index】: R965
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