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《ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY》 1999-11
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Influence of huMCP-1 fusion protein on the tumoricidal effect of peripheral blood monocyte in vitro

Wang Hantao, Guo Baoyu, Tan Yexiong, Tu Yue, Wang Yuanhe, Meng Ronggui(Department of General Surgery, Changhai Hospital, Second Military Medical University, Shanghai, 200433)  
Objective: To study the influence of huMCP 1 fusion protein on the tumoricidal effect of peripheral blood monocyte in vitro . Methods: Effect of huMCP 1 alone or jointly with cytokines on the tumoricidal capacity of monocyte was measured by the lactate dehydrogenase releasing. Results: Ten μg/ml huMCP 1 improved the tumoricidal effect of monocytes on human gastric adenocarcinoma SGC 7901 and human colonic cancer Hce 8693( P 0.01). 100 U/ml IFNγ and 1 μg/ml huMCP 1 increased the tumoricidal effect of monocyte on SGC 7901 and Hce 8693 jointly( P 0.05). The combination of 100 U/ml TNF and 0.1 or 1 μg/ml huMCP 1 produced joint activation of tumoricidal capacity of monocytes ( P 0.01). Conclusion: huMCP 1 can enhance the tumoricidal capacity of monocyte alone or jointly with TNF and IFNγ.
【Fund】: 国家自然科学基金
【CateGory Index】: R73-36
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