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《ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY》 2000-02
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Effects of ambroxol on pulmonary surfactant system ultrastructure in asthma guinea pigs

DENG Lin 2, FANG Feng 1, FANG Chao Ping 1, WU Yong Zheng 1 (1. Department of Pediatrics, Changhai Hospital, Second Military Medical University, Shanghai 200433, China; 2. Department of Pediatrics, the First People′s Hospital of Yichang, Yichan  
Objective: To explore the effects of ambroxol on pulmonary surfactant system(PSS) ultrastructure of asthma guinea pigs. Methods: Sixteen guinea pigs were divided into 4 groups: normal group,sensitized group,asthma group and asthma plus ambroxal treated group. We adopted electron microscope histochemistry method to observe the ultrastructure of PSS. Results: (1)The pulmonary surfactant layer lost its normal structure; congregated into pieces in the alveolar cavity and the lamellar bodies in type Ⅱ pneumonocytes were vacuolized in asthma group. (2) The pulmonary surfactant layer was continuous and the lamellar bodies in type Ⅱ pneumonocytes was slightly vacuolized in the asthma plus ambroxol treated group. (3) The ultrastructure of the sensitized group was similar to that of the asthma plus ambroxol treated group. Conclusion: The ultrastructure of PSS is obviously abnormal in asthma group. Ambroxol administration can reduce the ultrastructure change in PSS after asthma attack.
【CateGory Index】: R363
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【References】
Chinese Journal Full-text Database 2 Hits
1 LI Hui, FANG Feng, SUN Shu Mei, FANG Chao Ping, SUN Yu, MAN Li Xin (Department of Pediatrics, Changhai Hospital, Second Military Medical University, Shanghai 200433,China);Effect of pulmonary surfactant on expression of endothelin-1 and endothelin mRNA in rats with allergic asthma[J];Academic Journal of Second Military Medical University;2001-12
2 KANG Chunya n,LIU Changting,MAO Peiying.Respiratory Department of Nanlou,PLA General Hospital.Beijing,100853,China;Effects of dexamethasone on the ultrastructure of pulmonary surfactant system in guinea pig models of asthma[J];Chinese Journal of Respiratory and Critical Care Medicine;2004-06
【Co-citations】
Chinese Journal Full-text Database 1 Hits
1 Wu Yongzheng, Fang Feng, Fang Chaoping, Yang Yongji, Lu Yueliang (Department of Pediatrics, Changhai Hospital, Second Military Medical University, Shanghai, 200433);The ultrastructure changes of pulmonary surfactant system in asthma[J];ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY;1999-07
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 CUI Hujun 1△ , ZHANG Mingli 1, XIAO Feng 1, LI Yan 1,WANG Jin 1, CHEN Hongyi 2 (1. Department of Cardiac surgery, 2. Department of Thoracic surgery, Peking University First Hospital, Beijing 100034, China);Comparison and correlative analysis of pulmonary function markers after extracorporeal circulation[J];Journal of Beijing Medical University;2003-02
2 KONG Xiang-Yong, LUAN Bin, JIA Tian-Ming,et al. (Department of Pediatrics, Zhujiang Hospital, First Military Medical University, Guangzhou 5100282, China);Effect of Dexamethasone on the Cellular DNA Synthesis and Remodelling of Airway in Asthmatic Rats[J];Chinese Journal of Contemporary Pediatrics;2002-02
3 Hong-Xia Wei, Feng Fang, Chao-Ping Fang. Department of Pediatrics,Changhai Hospital, Shanghai 200433;Pathological study on therapy of pulmonary surfactant in the asthmatic model of guinea pigs[J];CHINESE JOURNAL OF CONTEMPORARY PEDIATRICS;1999-03
4 ZHENG Yan-hui,KUAN Shou-jing.Department of Pediatvics The 3rd Xiang Hospital,Central South University,Changsha,410013,China;Effect of Small and Large Ambroxol on Pulmonary Surfactant in Asthma Guinea-pig[J];Journal of Chinese Physician;2003-S1
5 NI Can-Rong; ZHENG Jian-Ming; ZHU Ming-Hua;MA Da-Lie; DAI Yi-Min (Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China);Preparation and application of catalyzed signal amplification system in immunohistochemistry and in situ hybridization[J];ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY;2000-04
6 LI Hui, FANG Feng, SUN Shu Mei, FANG Chao Ping, SUN Yu, MAN Li Xin (Department of Pediatrics, Changhai Hospital, Second Military Medical University, Shanghai 200433,China);Effect of pulmonary surfactant on expression of endothelin-1 and endothelin mRNA in rats with allergic asthma[J];Academic Journal of Second Military Medical University;2001-12
7 Wu Yongzheng, Fang Feng, Fang Chaoping, Yang Yongji, Lu Yueliang (Department of Pediatrics, Changhai Hospital, Second Military Medical University, Shanghai, 200433);The ultrastructure changes of pulmonary surfactant system in asthma[J];ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY;1999-07
8 $$$$;The determination of phospholipid in biological samples by HPLC[J];ACTA ACADEMIAE MEDICINAE MILITARIS TERTIAE;1996-01
9 ZHAO Shuang-ping *,GUO Qu-lian,WANG Rui-ke,WANG E (ICU of Xiangya Hospital,Central South University,Changsha 410008,China);Oxidative and anti-oxidative effects of ambroxol on acute hydrochloric acid-induced lung injury in rats[J];;2004-05
10 Miao Hui Xue Quanfu* Zhuang Fengyuan(Hemorheology Department, ChinaJapan Friendship Institute of Medical Scinences,Beijing 100029);Establishment of Asthmatic Model of Rats[J];BASIC MEDICAL SCIENCES AND CLINICS;1998-01
【Secondary References】
Chinese Journal Full-text Database 3 Hits
1 LI Hui,SUN Shumei,FANG Feng, et al. Pediatrics of the 88th hospital of PLA,Taian 271000, China;Effect of pulmonary surfactant on intercellular adhesion molecule -1 in rats with allergic asthma[J];Qianwei Journal of Medicine;2003-04
2 YE Ren-song,SHEN Hui-feng,XU Yi-ping,et al.(Department of Respiratory Medicine,Shanghai No.8 People's Hospital Affiliated to Jiangshu University,Shanghai 200233,China);Experimental Study of Pulmonary Surfactant Secretion in Asthmatic Guinea Pigs[J];Practical Preventive Medicine;2009-03
3 YANG Yong,LIU Ji-ning,LV Ru-qi et al (Department of Emergency,Mianyang Central Hospital,Mianyang 621000,Sichuan,China);Effects of potassium channel opener NS1619 on ultrastructure of pulmonary surfactant system in asthmatic rats[J];Medical Journal of West China;2008-03
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