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Antiviral action of Radix Isatidis and Folium Isatidis from different germplasm against influenza A virus

LIU Sheng 2, CHEN Wan Sheng 1, QIAO Chuan Zhuo 1, ZHENG Shui Qing 1, ZENG Ming 1,ZHANG Han Ming 1, SONG Zhao Jun 1 (1. Department of Pharmacognosy, College of Pharmacy, Second Military Medical University, Shanghai 200433, China; 2. Department  
Objective: To investigate the antiviral action of traditional Chinese medicine Radix Isatidis and Folium Isatidis . Methods: Influenza A virus was used to infect chicken embryo in vitro , the antiviral action of the drug samples from 15 different germplasm were studied. Results: According to hemagglutination titer, it was proved that most of Radix Isatidis and Folium Isatidis were effective to influenza A virus in 3 aspects: direct, therapeutic and preventive action. Moreover, the antiviral activity of crude drugs from different germplasm varied obviously. Conclusion: On the base of the high quality of crude drugs, we clarify the fact that Radix Isatidis and Folium Isatidis surely have the antiviral action, and preliminarily offer a scientific foundation for the choice of first rate germplasm.
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