Protective effects of ginsenoside Rg_1, Re on cultured hippocampal and cortex neurons injury induced by β-amyloid protein

ZHANG Xiao Dong, LI Wan Hai, WANG Qian, HUANG Mao, ZHOU Li Hua, TAN Ye Xiong (Department of Pharmacology, College of Pharmacy, Second Military Medical University, Shanghai 200433, China) [  

Objective: To study protective effects of ginsenoside Rg 1, Re on cultured cortex and hippocampal neurons injury induced by β amyloid protein (β AP). Methods: Lactic dehydrogenase (LDH) releasing assay was applied for measurement of the change of neuron cell injury. Results: After incubated with β AP (0.4 μmol/L) for 12 h, the releasing of LDH was significantly increased. Ginsenoside Rg 1 and Re 10, 20 μmol/L decreased releasing of LDH. Conclusion: Ginsenoside Rg 1, Re have protective effects on cultured cortex and hippocampal neurons injury induced by β AP. [

【Key Words】： ginsenoside Rg 1 ginsenoside Re hippocampal neurons cortex neurons neurons injuries
【Fund】： 国家自然科学基金资助项目!(39870 871)

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