Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Academic Journal of Second Military Medical University》 2001-02
Add to Favorite Get Latest Update

Effects of cytokines on the expression of CD40 and CD40 ligand in cultured human monocytes/macrophages

YAN Jin Chuan 1, WU Zong Gui 1, CHEN Jin Ming 1, HUANG Chao 2, ZHANG Ling Zhen 2, LI Li 2, ZHONG Ren Qian 2 ( 1. Department of Cardiovasology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China; 2. Department  
Objective: To investigate the effect of cytokines (IFN γ,TNF and IL 1) on the expression of CD40 and CD40 ligand (CD40L) in monocytes/macrophages. Methods: The mRNA expression of CD40 and CD40L was measured by RT PCR and the CD40,CD40L expression on the monocytes/macrophages were detected by flow cytometric analysis. Results: IFN γ,TNF and IL 1 could not only significantly up regulate the mRNA levels of CD40 and CD40L in cultured monocytes/macrophages, but also increase the expression of CD40 and CD40L. Antioxidant VitE could reduce the expression of CD40 and CD40L induced by IFN γ,TNF and IL 1. Conclusion: IFN γ,TNF and IL 1 can stimulate high expression of CD40 and CD40L . Antioxidant VitE can partially inhibit the expression of CD40 and CD40L induced by cytokines in cultured monocytes/macrophages. [
【Fund】: 国家重点基础研究 (973 )项目! (G2 0 0 0 0 5 690 3 )
【CateGory Index】: R392.11
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 3 Hits
1 Yan Jinchuan,Wu Zonggui,Huang Zuo et al .Changzheng Hospital, Second Military Med ical University, Shanghai 200003;THE CLINICAL SIGNIFICANCE OF HIGH EXPRESSION OF CD40L IN PATIENTS WITH ACUTE CORONARY SYNDROMES[J];Medical Journal of Chinese People's Liberation Army;2001-07
2 YAN Jin-Chuan, WU Zhong-Gui, ZHANG Ling-Zhen, LI Li, ZHONG Ren-Qian,and KONG Xian-Tao (Department of Cardiology,Changzheng Hospital,the Second Military Medical University, Shanghai 200003,China);The Relation of High Expression of CD40 Ligand with Unstable Angina[J];Chinese Journal of Arteriosc Lerosis;2001-05
3 YAN Jin Chuan, WU Zong Gui, CHEN Jin Ming 1, LI Li, ZHONG Ren Qian 1 (Dept of Cardiovasology, the Affiliated Zhongda Hospital, Southeast College, Nanjing 210009);Effects of cytokines on the expression of CD40 and CD40 ligand in cultured human umbilical vein endothelial cells[J];Chinese Pharmacological Bulletin;2003-02
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 WU Zong Gui 1, YAN Jin Chuan 1, ZHANG Ling Zhen 2, LI Li 2, ZHONG Ren Qian 2 (1. Department of Cardiovasology, Changzheng Hospital, Second Military Medical University, Shanghai 200003,China; 2. Department of Laboratory Diagnosis) [;Effects of oxidized low density lipoprotein and antioxidant vitamin E on the expression of CD40 and CD40 ligand in cultured human monocytes[J];Academic Journal of Second Military Medical University;2001-02
2 YAN Jin Chuan 1, WU Zong Gui 1, ZHANG Ling Zhen 2, LI Li 2, FAN Jie 3, LING Ling 3, HAN Wen Yu 3, ZHANG Suo Long 3 (1. Department of Cardiovasology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China; 2. Departmen;Effects of oxLDL and simvastatin on PKC activity and level of cytosolic free Ca~(2+) in cultured human umbilical vein endothelial cells[J];Academic Journal of Second Military Medical University;2001-02
3 ZHU Zhi-yun(Department of Medicine,The Second Hospital of Guangzhou Medical College,Guangzhou 510260,China);Clinical Studies on Plasma Adiponectin Level,Tumor Necrosis Factor-alpha in Patients with Primary Hypertension[J];Journal of Hubei University for Nationalities(Medical Edition);2009-01
4 YAN Jin-Chuan, WU Zong-Gui, HE Song-Qing, FAN Jie, and LING Ling (Department of Cardiovasology, Chang Zheng Hospital, Second Military Medical University, Shang hai 200003; 1.Department of Cardiovasology, The Fourth People 's Hospital of Zhenjiang, Zhe;Effect of Vitamin E on the Cytotoxicity and Proliferation Induced by Oxidized Low density Lipoprotein in Cultured Rat Aortic Smooth Muscle Cells[J];Chinese Journal of Arteriosc Lerosis;2001-04
5 YAN Jin-chuan,Fan Jie,LING Ling et al (Department of Cardiovasology,the Fourth People's Hospital of Zhenjiang,Zhenjiang,Jiangsu 212001,China);Effect of vitamin E on the cytotoxicity and proliferation of cultured umbilical vein endothelial cells induced by oxidized low density lipoprotein[J];EDITORIAL DEPARTMERT OF CHINESE JOURNAL OF GERIATRIC CARDIOVASCULAR AND CEREBROVASCULAR DISEASE;2000-05
6 GAO Jingsheng,YUAN Lei,HAO Bing,et al(Department of Cardiology,Kailuan Hospital Affiliated to North China Coal Medical College,Tangshan 063000,China);Change and significance of inflammatory factors in diabetic patients with acute myocardial infarction[J];Journal of North China Coal Medical College;2007-04
7 DU Deng gui,HE Hai ming,SHI Gen lin (Department of Cardiology,Jiangsu Provincial Corp Hospital,Chinese People′s Armed Police Force,Yangzhou Jiangsu 225003,China);Study of serum TNF,IL-6 levels in patients with coronary heart disease and their relationship[J];Chinese Heart Journal;2001-03
8 YAN Jin Chuan, WU Zong Gui, CHEN Jin Ming 1, LI Li, ZHONG Ren Qian 1 (Dept of Cardiovasology, the Affiliated Zhongda Hospital, Southeast College, Nanjing 210009);Effects of cytokines on the expression of CD40 and CD40 ligand in cultured human umbilical vein endothelial cells[J];Chinese Pharmacological Bulletin;2003-02
9 YAN Jin-chuan 1, WU Zong-gui 1, HE Song-qing 1, LING Ling 2, HAN Wen-yu 2, FAN Jie 2, ZHANG Suo-long 2 ( 1Department of Cardiovasology, Changzheng Hospital,Second Military Medical University, Shanghai 200003,China;? 2?Department of Cardi;Effects of oxidized low density lipoprotein and vitamin E on the levels of IL-6,IL-8 and TNF-α in cultured human umbilical vein endothelial cells[J];Chinese Journal of Pathophysiology;2001-10
10 YAN Jin-chuan 1, WU Zong-gui 1, ZHANG Ling-zhen 2, LI Li 2, FAN Jie 3, LING Ling 3, HAN Wen-yu 3, ZHANG Suo-long 3 (? 1?Department of Cardiovasology, 2 Department of Experimental Research, Changzheng Hospital, Second Military Medic;Effect of OX-LDL and simvastatin on PKC activity and cytosolic free Ca~(2+) in cultured rat aortic smooth muscle cells[J];Chinese Journal of Pathophysiology;2002-04
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 XIAO Tie hui, WANG Zong ren, LI Jing hua, MA Shi ping, MA Jing, XIA Tian,LI Jun chang (Xijing Hospital, the 4th Militity Medical University,PLA,Shaanxi Xi′an 710032, China);EFFECT OF QIDAN TONGMAI TABLET ON BLOOD LIPID, HEMORRHEOLOGY AND RED BLOOD CELL MEMBRANE FLUIDITY IN RATS WITH HYPERLIPEMIA[J];Journal of Anhui Traditional Chinese Medical College;2002-01
2 WU Zong Gui 1, YAN Jin Chuan 1, ZHANG Ling Zhen 2, LI Li 2, ZHONG Ren Qian 2 (1. Department of Cardiovasology, Changzheng Hospital, Second Military Medical University, Shanghai 200003,China; 2. Department of Laboratory Diagnosis) [;Effects of oxidized low density lipoprotein and antioxidant vitamin E on the expression of CD40 and CD40 ligand in cultured human monocytes[J];Academic Journal of Second Military Medical University;2001-02
3 MA Shi Ping, ZHANG Mei, WANG Zong Ren Department of Traditional Chinese Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an 710033, China;Effect of Huoxue Tongmai Tablet on blood- lipid and hemorheology in patients with hypertension[J];JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY;2000-03
4 MA Shi Ping 1, WANG Zong Ren 1, LONG Yin 1,XING LI 1,LI Jun Chang 1,FANG Kun Quan 2 1Department of Traditional Chinese Medicine, Xijing Hospital, 2Department of Pharmacology, Faculty of Preclinical Medicine,Fourth Military Medical U;Pharmacological effects of Qidan tongmai tablet on hyperlipemia[J];JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY;2000-04
5 HANG Li 1, MA Jing 1, WANG Zong Ren 1, YANG Xi Zhong 2, MA Shin Pin 1, LI Meng Meng 3, XIAO Tie Hui 1, LI Jing Hua 1, ZHENG Jin 1 1Department of Traditional Chinese Medicine, 2Department of Pharmaceutics, 3Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xian 710033, Chain;Effects of Qidantongmai tablet on acute myocardial ischemia injury in rats[J];Journal of The Fourth Military Medical University;2003-05
6 ZHENG Jin 1, WANG Zong Ren 1, MA Ai Ling 1, LIU Qiang 2, SU Ming Quan 3, FANG Kun Quan 4, MA Shi Ping 1, MA Jing 1, YUE Qiao Hong 3 1Department of Traditional Chinese Medicine, 3Department of Clinical Laboratory, 4Department of Pharmacy,Xijing Hospital, Fourth Military Medical University, Xian 710033, China, 2Department of Hematology,Tangdu Hospital, Fourth Military Medical University, Xian 710038, China;Effects of Qidantongmai tablets on CD40 expression of aorta and monouncleus cells in atherosclerosis rats[J];Journal of The Fourth Military Medical University;2004-06
7 Wu Wenxin; Zhu Guangjin; Duan Yanping (Institute of Basic Medical Sciences. CAMS.Beijing 100005);Changes of Fibrinolytic Factors Expression of Coronary Arteries in Acute Myocardial Infarction[J];BASIC MEDICAL SCIENCES AND CLINICS;1997-01
8 WANG Chuiling, LI Jianxian, LIU Yuan, et al The first Affilited Hospital of Shanxi medical University,Taiyuan(030001)$$$$;The Effects and Mechanism of Fluvastatin on Renal Fibratic Rats[J];Chinese Journal of Integrated Traditional and Western Nephrology;2001-06
9 SUN Xuefeng, ZHOU Xijing, WANG Lining Department of Nephrology, First Affilliated Hospital,Sun Yat-sen University of Medical Sciences, Guangzhou (510080);Proteinuria Aggravate Hypercoagulation in Patients with Diabetic Nephropathy[J];Chinese Journal of Integrated Traditional and Western Nephrology;2002-06
10 JIANG Yu; LIU Bing-Wen; FAN Ping; LIU Yu andZHANG Rong-Jue(Apolipoprotein Research Unit, Institute of Biochemistry and Molecular Biology, West China University of Medical Sciences, Chengdu 610041, China);Oxidative Modification of Plasma Low Density Lipoprotein, Very Low Density Lipoprotein and High Density Lipoprotein in Endogenous Hypertriglyceridemia[J];Chinese Journal of Arteriosc Lerosis;1997-02
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 He Shuxian Ye Xiulin Chen Chao The People's Hospital of Futian District,Shenzhen,Guangdong Province,518033;Effects of Therapy of Activating Blood to Resolve Stasis on Serum sCD40L in Acute Coronary Syndrome(ACS)[J];Guangxi Journal of Traditional Chinese Medicine;2007-02
2 WU Xin-hua1, ZHANG Hua2, FU Hai-qing1, LI Ze1, WU Zong-gui2 (1. Department of Cadre Ward, PLA 425 hospital, Sanya, Hainan 572008 China; 2. Department of cardiology, Changzheng hospital, Second Military Medical University, Shanghai 200003 China);Correlation between Peroxisome Proliferator-activated receptor gamma and CD40/CD40L in patients with acute coronary syndrome[J];Hainan Medical Journal;2007-01
3 ;Effect of the Method of Heat-clearing,Detoxicating and Promoting Blood Flow to Dissolve Blood Stasis on the sCD40L in Blood Serum of the Patient With Acute Coronary Artery Syndrome[J];Guiding Journal of TCM;2006-07
4 PENG Dao Quan, ZHAO Shui Ping, LI Jiang, and ZHOU Hong Nian (Department of Cardiology, the Second Xiang Ya Hospital of Central South University, Changsha 410011, China);The Relation of Soluble Serum CD40 Ligand Level and Acute Coronary Syndrome[J];Chinese Journal of Arteriosc Lerosis;2002-02
5 CHU Luo-Xiang,JIAN De-Qian,and LIU Zhao-Yun(Department of Cardiology,the Second Xiangya Hospital of Central South University,Changsha 410011,China);The Effects of Pioglitazone on the Expression of CD40L in High-Cholesterol Diet Rabbit Aorta[J];Chinese Journal of Arteriosclerosis;2006-06
6 ZHANG Zhi-Hui1,LI Xu-Ping2,ZHOU Sheng-Hua2,and QI Shu-Shan2(1.Department of Cardiology,Third Xiangya Hospital,Central South University,Changsha 410013;2.Department of Cardiology,Second Xiangya Hospital,Central South University,Changsha 410011,China);Relation of CD40 Ligand,Pregnancy-Associated Plasma ProteinA and Malondialdehyde-Modified Low Density Lipoprotein to Angiographic Morphology of Coronary Lesions in Patients with Coronary Heart Disease[J];Chinese Journal of Arteriosclerosis;2007-02
7 CHEN He,WANG Qi-xian,DENG Dong-bo,ZHU yan-xia,FANG Qin(Dept.of Cardiology,The 1st Affiliattd Hospital of Kunming Medical College,Kunming 650032,China);Serum Soluble CD40L Level and its Application in Coronary Heart Disease[J];Journal of Kunming Medical College;2006-01
8 CHEN Ying-min, SONG Wei, LIU Jian-ping, XU Jin, ZANG Min-hua, DING Hong-yi, XIE Xiu-lan, XU Yi-min, WANG Bin-yao (Department of Cardiology, Renji Hospital, Shanghai Second Medical University, Shanghai200001, China);Effect of Tong-Xin-Luo Therapy on Serum sCD40L in Patients with Acute Coronary Syndromes[J];Acta Universitatis Medicinalis Secondae Shanghai;2005-07
9 LIN Tao,MA Yi-tong(Department of Cardiology,The First Affiliated Hospital of Xinjiang Medical University,Urümuqi 830054,China);Progress in Studies of Cardiac Markers and Their Clinical Application in ACS[J];Advances in Cardiovascular Diseases;2008-04
10 WU Zhi-ting,MEI Yong-jun,CAO Ping-liang,et al. Jiangxi Cardiovascular Research Institute/JiangXi Provincial People`s Hospital,Nanchang 330006,China;The relationship between soluble CD40 ligand,myeloperoxidase,high sensitivity C-reactive protein and acute coronary syndrom[J];Chinese Journal of Cardiovascular Review;2008-10
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved