Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Academic Journal of Second Military Medical University》 2002-01
Add to Favorite Get Latest Update

Oxidative injury mechanism of acute cadmium-exposed rat testis

ZHOU Yong, JIN Hui-Ying,FENG Wei-Hua, HU Hui-Min, ZHENG Zun, YIN Mu-Quan(1. Department of Biochemistry and Molecular Biology, Department of Basic Medicine, Second Military Medical University, Shanghai 200433, China; 2. Department of Cell Biology; 3. Depar  
Objective: To study the role of metallothionein in cellular antioxidant system and the reason of testis highly sensitive to cadmium(Cd). Methods: Changes of cellular antioxidant system in acute Cd 2+ exposed rat testis and liver were observed. Indexes included oxidant damage index (MDA and deoxidized GSH), activities of cellular antioxidant enzymes (SOD, CAT and GSHpx) and MT expression level. Results: A single dose Cd 2+ exposure would cause lipid peroxidation, excessive ROS production and loss of intracellular redox potential in both testis and liver. Their patterns of changes were different: the former oxidant damage quickly lightened since MT was induced in 6 h group in liver, although it was not so serious in first 3 h in testis, the oxidant injury was not controlled by 48 h. MT could be induced in testis until 48 h after acute Cd 2+ exposure. Conclusion: Metallothionein plays a major role in the cellular antioxidant defense system, it is a highly effective eliminator of Cd. MT can't be induced in testis is the important reason that testis is highly sensitive to Cd.
【Fund】: 国家自然科学基金资助项目 ( 39970 6 31)
【CateGory Index】: R595.2
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 2 Hits
1 DIAO Shu-yong~(1),ZHANG Li-zhi~(2) ,YUAN Hui~(1) (1.College of Animal Science & Technology, Hunan Agricultural University, Changsha,Hunan,410128,China; 2.Iinstutute of Animal Husbandry & Veterinary ,Jinzhou Medicine College,Jinzhou,Liaoning,121001,China);Progress in the Toxicity Mechanism of Cadmium[J];Progress In Veterinary Medicine;2005-05
2 QIU Ji(Office of Scientific Research,Huzhou Vocational& Technological College,Huzhou 313000,China);Review of the Male Reproductive Toxicity by Cadmium[J];Journal of Huzhou Vocational and Technological College;2008-03
Chinese Journal Full-text Database 2 Hits
1 Jin Huiying, Zhou Yong, Hu Huimin, Feng Weihua,Zhao Lin, Liu Junhua(Department of Biochemistry, Department of Basic Medicine, Second Military Medical University, Shanghai, 200433);Purification of cadmium induced rat metallothionein and its antiserum preparation[J];ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY;1997-02
2 ZHOU Yong\ JIN Hui ying *\ HU Hui min *\ YU Bing xue WEI Yao mei *\ ZHENG Zun (Biophysics Program,*Biochemistry Program,Department of Basic Medicine,Second Military Medical University,Shanghai 200433,China.);Ultrastructural localization of metallothionein in acute cadmium exposed rat liver[J];JOURNAL OF CHINESE ELECTRON MICROSCOPY SOCIETY;1999-03
Chinese Journal Full-text Database 10 Hits
1 HUANG Qiu-chan et al(Department of Chemistry and Life Science,Nanning Teachers College,Longzhou,Guangxi 532400);Review on the Toxicological Effect and the Mechanism of Cadmium to Human Health[J];Journal of Anhui Agricultural Sciences;2007-09
2 LEI Xiao-zhu et al(Tangshan Vocational & Technical College,Tangshan,Hebei 063004);Comparison of Superoxide Dismutase Isoenzymes in Three Shrimps[J];Journal of Anhui Agricultural Sciences;2008-26
3 WANG Ya-bin et al (Environmental Monitoring Station of Baoding,Baoding,Hebei 071002);Effect of Vitamin B6 in Feed on Part of Immune Function for Macrobrachium Nipponense[J];Journal of Anhui Agricultural Sciences;2009-17
4 Zhang Mei,Wang Zongren,Xia Tian,Yu Wenbing,Zhang Zhonghai,Ma ShiPing (Xijing Hospital,the 4th Military Medical University,Xi’an 710032,China);EFFECT OF JIANGNIAN KANGSHUAN TABLET ON THE RED BLOOD CELL MEMBRANE FLUIDITY IN DIABETES[J];JOURNAL OF ANHUI TRADITIONAL CHINESE MEDICAL COLLEGE;2000-03
5 GUO Li-ge1,YANG Li-kun1,ZHAO Jian-hua1,QI Li-jun2,WANG Hong-wei1(1.College of Life Science,Hebei University,Baoding 071002,China;2.Development Department,Hebei Chenguang Natural Pigment Limited Company,Handan 056000,China);Effects of Dietary Selenium Supplementation on the Activities of Two Antioxidant Enzymes in Prawn Caridina denticulata sinensis Exposed to Ambient Sodium Polyphosphate[J];Fisheries Science;2008-02
6 WANG Hong-wei1,CAI Duan-bo2,LIANG Ai-min3,CHEN Li-jun1①,HUO Yan-gao1②(1.College of Life Sciences,Hebei University,Baoding 071002,China;2.College of Quality and Technical Supervision,Hebei University,Baoding 071002,China;3.Shengli Road Primary School,Huai'an County,Zhangjiakou 075024,China);Effects of Dietary Mn Supplementation on Superoxide Dismutase(SOD) Activity in Prawn Caridina denticulata sinensis Exposed to Cypermethrin[J];Fisheries Science;2009-03
7 WANG Wei-wei1,LIU Cun-qi2,LI Dao-ji1,ZHANG Ya-juan2(1.State Key Laboratory of Estuarine and Coastal Research,East China Normal University,Shanghai 200062,China;2.College of Life Science,Hebei University,Baoding 071002,China);Partial Characterizations of Superoxide Dismutase in Three Species of Shrimps[J];Fisheries Science;2009-04
8 HAN Qiang LIN Hui fen ZHU Lin li (Shanghai daily Chemical Industrial Research Institute,Shanghai 200062,China);The Scavenging Effects of some Natural Products on Superoxide and Hydroxyl Radicals[J];CHINA SURFACTANT DETERGENT & COSMETICS;2000-03
9 CHEN Wei-qing~1,LOU Dong-ping~2 (1.Zhejiang Shuren University,Hangzhou310015,China;2.Hangzhou Wahaha Group Company Ltd.,Hangzhou310018,China);Research for anti-aging function of bath lotion with Chinese herbal medicine[J];China Surfactant Detergent & Cosmetics;2004-05
10 Guo Chunhua Lin xiuzhen Zhang Caili ChangZhi medical college(046000),;The Experimental Study of DaChengQi Decoction Resisting Free-radical Damage[J];JOURNAL OF CHANGZHI MEDICAL COLLEGE;1998-02
Chinese Journal Full-text Database 10 Hits
1 LIN Zhong ning, DONG Sheng zhang, CAI Ying, DONG Shu yun, YU Gui ying, REN Tie ling (Department of Environmental Health, Sun Yat sen University of Medical Sciences, Guangzhou 510089, China);IN VITRO STUDY ON THE DNA INJURIES AND REPAIR OF SPLENIC LYMPHOCYTE INDUCED BY CADMIUM-METALLOTHIONEIN[J];CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS;2000-02
2 JIN Long_jin,LOU Zhe_feng,DONG Jie_ying,et al (Central Laboratory of Biology,Wenzhou Medical Collage,Wenzhou325027,China);Effects of Cadmium and Mercury on DNA Damage of Mice Bone Marrow Cell and Testicle Germ Cell in vitro[J];Carcinogenesis,Teratogenesis and Mutagenesis;2004-02
4 PANG Hui min l,ZHU Yu zhuo 1,LIU Nian zhi 2 (1. Dept.of Medical Genetics,School of Basic Medical Sciences,Jilin University, Changchun 130021, China;2.The People Hospital of Jilin Province);Effect of Herba leonuri on the micronucleus frequencies induced by CdSO_4 in the bone marrow cells of mice[J];Journal of Norman Bethune University of Medical Science;2002-05
5 Luo Ziguo, Xu Ge ,Li Weixin Laboratory of Electron Microscopy, Chongqing University of Medical Laboratory of Electron Microscopy, Chongqing University of Medical Sciences, Chongqing, 400016;Study of the Injurious Effects of Cadmium and Protective Action of Zinc on Ultrastructure of Basal Cell of Prostate in Rat[J];Chongqing Medical Journal;2000-05
6 XU Jing-bo~1,YANG Li~1,ZHAO Li-qun~1,SUN Zhi-wei~2,SHI Long~2(1.Department of Environmental Science and Engineering,Northeast Normal University,Changchun 130024,China;2.College of Preventive Medicine,Jilin University,Changchun 130026,China);SCGE sduty on DNA damage of spermary cell in mice induced by m-nitrobenzene[J];Journal of Northeast Normal University (Natural Science Edition);2005-03
7 ZHANG Jian Peng, ZHONG Yan, REN Xu Yi,ZHOU Yong, FENG Wei Hua *, JIAO Bing Hua(Department of Biochemistry and Molecular Biology,College of Basic Medical Sciences, Second Military Medical University, Shanghai 200433,China);Cell-and time-dependent metallothionein gene expression in testes of rats treated with cadmium[J];Academic Journal of Second Military Medical University;2003-02
8 Yang Shuixiu, Gao Shiyun (Guiyang Environmental Montoring Center Station, Guiyang 550002);ATMOSPHERE LEAD-CADMIUM-NICKEL POLLUTION AND ITS CURRENT STATUS IN GUIYANG CITY[J];Geology-geochemistry;2002-02
9 MOU Su-hua, MENG Wei-xing (College of Medicine, Hubei Institute for Nationalities, Enshi, 445000,China);Ability of Fluorine, Selenium and Cadmium in Lipid Peroxidating and Anti-oxidation on Rats[J];Journal of Hubei Institute For Nationalities Medical Edition;2003-01
【Secondary References】
Chinese Journal Full-text Database 9 Hits
1 LIN Hai1,YU Xiao-bo1,GONG Hua1,DONG Xiao-li1,SUN Yu-mei21.School of Chemistry Engineering and Material,Dalian Polytechnic University,Dalian 116034,China; 2.School of Biological & Food Engineering,Dalian Polytechnic University,Dalian 116034,China;Investigations on heavy metal sedimentation of cadmium from marine shellfish and cadmium discharge by green algae,selenium and zinc[J];Journal of Dalian Polytechnic University;2009-02
2 Zhao Yan, Kong Qiang, Fu Rongshu(College of Life Science,Shandong Normal University,Jinan 250014,China);Single and joint toxicity of Cu~(2+),Cd~(2+) and Cr~(6+) on Poecilia reticulata[J];Water Technology;2009-06
3 FAN Li-jun,ZHOU Zhong-liang,CHEN Dong-hua,ZHAO Yun-long,SUN Ju-xiang,WANG Qun(School of Life Science,East China Normal University,Shanghai 200062,China);Study on DNA Damage Induced by HgCl_2 and CdCl_2 Using SCGE in Eriocheir Sinensis Sperms(In Vitro)[J];Journal of East China Normal University(Natural Science);2007-04
4 HU Qing~1,QI Hong-yan~1,DOU Min-na~(1,2),ZHANG Hong-xun~1(1.Department of Environmental Biotechnology,Research Center for Eco-Environmental Sciences,Chinese Academy of Sciences,Beijing 100085,China;2.Biology Science and Technology College,Beijing Forestry University,Beijing 100083,China);Isolation,Molecular Characterization and Resistance Mechanism Study on a Cadmium Hyperresistant Bacillus cereus[J];Environmental Science;2007-02
5 Ou Xiaobing,Li Haiyun,Chen Yonghuang,Lu Wenfang.(College of Animal Science,South China Agricultural University,Guangzhou Guangdong 510642);Toxicity and toxic effects of heavy metals cadmium and copper on Hydra sp.[J];Environmental Pollution & Control;2006-08
6 HE Baoxia1,2,FU Yequan2,LI Jinlong1,XU Shiwen1,1.Department of Veterinary Medicine, Northeast Agricultural University, Harbin 1500302.Department of Animal Science, Zhoukou Vocational and Technical College, Zhoukou 466001;Effect of cadmium on the expression of Fas and caspase-3 mRNA in chicken anterior pituitary[J];Acta Scientiae Circumstantiae;2008-07
7 ZHU Ai-Yi, XIE Jia-Yan (Marine Science and Technology School, Zhejiang Ocean University, Zhoushan, 316004);EFFECTS OF CADMIUM ON SERUM TRANSFERRIN AND ERYTHROCYTES OF BOLEOPHTHALMUS PECTINIROSTRIS[J];Oceanologia Et Limnologia Sinica;2007-06
8 NING Jin-song1,2,ZHAI Yu-xiu1,2,SHANG De-rong1,2,ZHANG Cui1,3(1. Key Laboratory for Sustainable Utilization of Marine Fisheries Resources,Ministry of Agriculture,Yellow Sea Fishery Research Institute Chinese Academy of Fishery Sciences,Qingdao 266071,China;2. The National Center for Quality Supervision and Test of Aquatic Products,Qingdao 266071,China;3. College of Food Science and Engineering,Ocean University of China,Qingdao 266003,China);The prelimimary research on limits to cadmium in prawn formula feed[J];Marine Sciences;2009-04
9 HOU Jian-jun 1,2,3,4,ZHANG Qing-shun 3,XIONG Bang-xi 3*,ZOU Gui-wei 1,4 (1.Key Laboratory of Freshwater Ecology and Aquaculture/Yangtze River Fisheries Research Institute,Chinese Academy of Fishery Sciences,Jingzhou 434000,China; 2.College of Life Sciences,Hubei Normal University,Huangshi 435002,China;3.College of Fisheries,Huazhong Agricultural University,Wuhan 430070,China;4.Freshwater Fisheries Research Center,Chinese Academy of Fishery Sciences,Wuxi 214081,China);Studies on toxicological effects of cadmium in Bellamya purificata[J];Journal of China Agricultural University;2009-03
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved