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《Academic Journal of Second Military Medical University》 2002-01
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Oxidative injury mechanism of acute cadmium-exposed rat testis

ZHOU Yong, JIN Hui-Ying,FENG Wei-Hua, HU Hui-Min, ZHENG Zun, YIN Mu-Quan(1. Department of Biochemistry and Molecular Biology, Department of Basic Medicine, Second Military Medical University, Shanghai 200433, China; 2. Department of Cell Biology; 3. Depar  
Objective: To study the role of metallothionein in cellular antioxidant system and the reason of testis highly sensitive to cadmium(Cd). Methods: Changes of cellular antioxidant system in acute Cd 2+ exposed rat testis and liver were observed. Indexes included oxidant damage index (MDA and deoxidized GSH), activities of cellular antioxidant enzymes (SOD, CAT and GSHpx) and MT expression level. Results: A single dose Cd 2+ exposure would cause lipid peroxidation, excessive ROS production and loss of intracellular redox potential in both testis and liver. Their patterns of changes were different: the former oxidant damage quickly lightened since MT was induced in 6 h group in liver, although it was not so serious in first 3 h in testis, the oxidant injury was not controlled by 48 h. MT could be induced in testis until 48 h after acute Cd 2+ exposure. Conclusion: Metallothionein plays a major role in the cellular antioxidant defense system, it is a highly effective eliminator of Cd. MT can't be induced in testis is the important reason that testis is highly sensitive to Cd.
【Fund】: 国家自然科学基金资助项目 ( 39970 6 31)
【CateGory Index】: R595.2
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