Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Academic Journal of Second Military Medical University》 2002-03
Add to Favorite Get Latest Update

Studies on antineoplastic constituents from marine organisms in south China sea

YI Yang Hua 1,LI Ling 1,LIN Hou Wen 1,LI Wen Lin 1,YAO Xin Sheng 2,TANG Hai Feng 1,XU Qiang Zhi 1,ZOU Zheng Rong 1,SUN Peng 1,ZHANG Shu Yu 1,LIU Bao Shu 1 (1. Research Center for Marine Drugs,College of Pharmacy,Second Military Medical  
Objective: To search for bioactive constituents from marine organisms including Bugula neritina L., Phakellia fusa Thiele and Suberites tylobusa Levi. Methods: Using bioassay guidance,the bioactive compounds were isolated by multi chromatography and their structures were identified by spectral analysis. Results: Nine compounds were obtained and identified from Bugula neritina L., all showing a significant anticancer activity; Ten compounds were obtained from Phakellia fusa Thiele,among them 6 compounds were identified. Compound Ⅳ and Ⅴ showed an anti inflammatory activity and were effective on artificially induced rat arthritis model; Thirty compounds were obtained from Suberites tylobusa Levi and 14 compounds were identified,compound Ⅱshowed an antitumor activity. Conclusion: Several compounds are isolated from Bugula neritina L., Phakellia fusa Thiele and Suberites tylobusa Levi with various biological activities,this researches is of prospective values in the development of new drugs and utilization of marine organism resources.
【Fund】: 国家自然科学基金资助项目 ( 2 9672 0 5 0 )
【CateGory Index】: R284
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved