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《Academic Journal of Second Military Medical University》 2002-03
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Studies on antineoplastic constituents from marine mollusc sea hare (Ⅱ)

LIN Hou Wen 1,TANG Hai Feng 2,LIU Gao Lin 1,ZHANG Chun 1,SHEN Yang 1,YI Yang Hua 2,WU Hou Ming 3 (1.Department of Pharmacy,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China; 2.Research Center for Marine Drugs,College  
Objective:To investigate the antineoplastic constituents of sea hare Notarchus leachii freeri .Methods:Antineoplastic compounds were screened from sea hare by bioassay guided method with conidia of Pyricularia oryzae ,and by a combination of partition and purification with suitable solvent and multiple column chromatographies.Structures of active compounds were determined on the basis of spectral analysis.Results:Two active compounds were screened and the structures were elucidated as 3β hydroxy 5α,6α epoxycholesta 8 ene 7 one (Ⅰ) and 3β,7α dihydroxy 5α,6α epoxycholesta 8 (14) ene (Ⅱ).Conclusion:Compound Ⅰ is a new natural product,and compound Ⅱ is isolated from this animal for the first time,both of them have potential antineoplastic activities in vitro .
【Fund】: 国家自然科学基金资助项目 ( 30 0 0 0 2 19) ;; 中国科学院上海有机化学研究所生命有机国家重点实验室资助课题( 2 0 0 10 710 )
【CateGory Index】: R284
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