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《Academic Journal of Second Military Medical University》 2002-11
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Effects of Centella asiatica total triterpene fractions on endocrine function in depression rats

CHEN Yao, QIN Lu-Ping, ZHENG Han-Chen, RUI Yao-Cheng, ZHANG Qiao-Yan, ZHENG Qing-Ming(Department of Pharmacognosy,College of Pharmacy,Second Military Medical University,Shanghai 200433,China; Department of Pharmacology,College of Pharmacy)  
Objective: To study the effects of total triterpene fractions of Centella asiatica(TTFCA)on the function of hypothalamus-pituitary-adrenal axis and hypothalamus-pituitary-thyroid axis. Methods: The contents of adrenocoticotrophic hormone (ACTH) in the plasma and TSH, T3, T4, rT3 in the serum in depression animals caused by chronic unpredictable stress test were measured 21 d after oral administration of TTFCA (30, 60 or 120 mg/kg). Results: Compared with control animals, the contents of ACTH and TSH,T4,rT3 in depression animals decreased, while the contents of T3 increased significantly. Compared with model animals, the contents of ACTH and TSH,T4,rT3 of TTFCA treated animals increased but T3 decreased significantly. Conclusion: TTFCA can ameliorate the function of hypothalamus-pituitary-adrenal axis and hypothalamus-pituitary-thyroid axis.
【Fund】: 国家自然科学基金资助项目(30100242);;上海-联合 利华研究与发展基金(9802).
【CateGory Index】: R285.5
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