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《Academic Journal of Second Military Medical University》 2003-08
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Production of SARS-related anti-lung autoantibodies

CHEN Hao, LI Bo An, ZHAO Jun, HE Wei Ping, ZHENG Yu, LI Jing, GAO Rong, CHENG Yun *(Deparment of Immunology,Institute of Infectious Diseases,No.302 Hospital of PLA,Beijing 100039,China)  
Objective:To analyze the cross reactivity of SARS related autoantibodies and lung tissues. Methods: The anti SARS virus antibodies were detected by ELISA. Antibodies cross reative with SARS virus and lung tissues were absorbed by lung tissue. Results: After absorption by lung tissues,the anti SARS virus antibodies in the sera of SARS patients were partly absorbed; the absorption rate of IgG ranged from 13.6% to 32.2%. Conclusion: Part of anti SARS virus antibodies can react with lung tissue. There are possible common epitopes between SARS virus and lung tissue. Cross reactivity can partly explain the production of SARS related anti lung autoantibodies in the sera of SARS patients.
【Fund】: 国家自然科学基金 ( 3 0 3 40 0 10 ) ;; 北京市自然科学基金 ( 70 3 0 45 0 )
【CateGory Index】: R511.9
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