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《Academic Journal of Second Military Medical University》 2003-09
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Clinical transplantation of human neural stem cells in treatment of Parkinson disease

TIAN Zeng Min *, LIU Shuang, LI Shi Yue,ZHAO Quan Jun,YIN Feng, HAO Qiu Xing,ZHOU Ying (Institute of Neurosurgery, General Hospital of Navy, Beijing 100037, China)  
Objective:To study the clinical effect of transplanting human neural stem cells in treatment of Parkinson disease (PD). Methods: The cells from human fetal forebrain (5 11 weeks gestation) were expanded in vitro and differentiated into dopamine neurons, which were then implanted in PD striatum with stereotactic operation in 50 PD patients from Nov. 2000 to Nov. 2002. Results: The cells of fetal forebrain could be expanded by 10 7 fold in undifferentiated state for more than one year, and they could be turned into dopamine neurons. After 8 30 months (averagely 24 months) follow up,the effective rate of operation was 92%. Conclusion: It is feasible to implant the neural stem cells expanded in vitro for long period in treating PD.
【Fund】: 国家高新技术发展规划 ( 863 )课题( 2 0 0 1AA42 2 110 ) .
【CateGory Index】: R742.5
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