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《Academic Journal of Second Military Medical University》 2003-12
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Effect of gypenosides on hepatic function and fibrosis in rats with immune fibrosis

WAN Li, WAN Xing-Wang, HU Jin-Hong (1. Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 200433, China; 2. International Cooperation Laboratory of Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Shanghai 200438)  
Objective:To study the effect of gypenosides (GPs) on the hepatic function and fibrosis progression in Wistar rats with immune fibrosis. Methods: The model of immune fibrosis was established by injection of human albumin. Rats in treated group were also administered with 0. 5 mg GPs during 30 d human albumin attack. The hepatic function of rats was e-valuated by determining the levels of ALT, TBIL and TBA in serum. The progression of hepatic fibrosis was evaluated by the levels of HA, PC Ⅲ and LN by radioimmunoassay (RIA) and confirmed by rats tissue pathology analysis. Results: Albumin injection significantly elevated the levels ALT, TBIL, TBA, HA, PCⅢ(P0. 01) ,and LN(P0. 05), while GPs treatment significantly down-regulated the levels of ALT, TBIL, TBA,HA, PC Ⅲ (P0. 01),and LN(P0. 05) in Wistar rats with immune fibrosis. GPs treatment also reduced the production of collagen fibre induced by albumin injection and improved histo-logical changes of hepatic fibrosis significantly. Conclusion: GPs can protect the hepatic function of rats and inhibit the progression of hepatic fibrosis.
【Fund】: 国家自然科学基金(30000159)
【CateGory Index】: R285
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