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《Academic Journal of Second Military Medical University》 2004-03
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Expression of TGF-β in fracture fixed by swan-like memory-compressive connector

GAO Tang Cheng 1,ZHANG Chun Cai 1* ,KANG Qing Lin 1,XU Shuo Gui 1,NI Can Rong 2,WANG Zhi Wei 1, FU Qing Ge 1 (1. Department of Orthopaedics, Changhai Hospital, Second Military Medical University,Shanghai 200433,China; 2. Department of Pathology, Changhai Hospital)  
Objective:To study the effect of internal fixation with swan like memory compressive connector(SMC) on temporal expression patterns of TGF β at fracture site. Methods:Double sided humeral fracture in 35 New Zealand rabbits were internally fixed by SMC or dynamic compression plate(DCP) severally. Animals were killed in group of 5 at different time points(1,3,7,14,21,28,56 d post operatively), and immunohistochemistry(EnVision) combined with computer image analysis system was used to examine distribution and density of TGF β at fracture sites. Results:The TGF β staining was localized to the mesenchymal cells, osteoblasts, chondrocytes and extracellular matrix during fracture healing. At the early and late stage after operation, no significant differences of local TGF β content were found between the 2 groups. From day 7 to day 28, the expression of local TGF β in SMC group was significantly stronger than that in DCP group. Conclusion:The sustained dynamic memory compressive stress produced by SMC may enhance the biosynthesis and excretion of TGF β at fracture sites, thus promote bone healing.
【CateGory Index】: R687.3
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