Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Academic Journal of Second Military Medical University》 2004-10
Add to Favorite Get Latest Update

Protective effect of tremella polysaccharides on experimental aging mouse model

LI Yan, CAI Dong-Lian, HU Tong-Jie , CHEN Xiao-Li (Department of Clinical Nutriology,Changhai Hospital,Second Military Medical University,Shanghai 200433,China)  
Objective:To observe the protective effect of tremella polysaccharides (TP) on mouse aging model induced by D-galactose. Methods: Forty male ICR mice were divided into 5 groups (Group A: treated with 800 mg/kg TP; Group B: treated by 400 mg/kg TP; Group C: treated by 200 mg/kg TP; Group D: aging control; Group E: normal control). Except for Group E,other groups were injected with D-galactose [120 mg/(kg·d)] for 60 d to establish subacute aging model. Group A,B and C were treated with 800,400 and 200 mg/kg TP respectively via intragastric (i.g.) administration. Sixty days later,the spleen,heart, kidney and brain were collected to determine MDA, LP, SOD, GSH-Px and contents of hydroxyproline by colorimetry. Expression of P21 in the kidney were detected by immunohischemical technique. Proliferation and transformation of spleen lymphocytes induced by ConA were determined by MTT method. Results: Antioxidants SOD and GSH-Px activity of TP treated groups were higher than aging control group (P0.05); MDA and LP of TP treated groups were also lower than those of aging control group (P0.05). TP obviously promoted the lymphocytes to proliferate induced by ConA in vitro. Furthermore, in TP treated groups, the kidney expression of cell cycle regulator P21 were lower and hydroxyproline contents in the skin were higher than those in Group D (P0.05). Conclusion: It is suggested that TP can prevent aging of mice induced by D-galactose.
【Fund】: 上海市科委发展基金 ( 0 2 41190 48)
【CateGory Index】: R285
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 3 Hits
1 TAO Ming-xuan1,WANG Feng1,WANG Xiao-wei1,JIN Peng1,CHENG Guang-yu2,3(1.Jinling College,Nanjing Normal University,Nanjing 210097,China;2.School of Life Science,Nanjing Normal University,Nanjing 210097,China;3.Jiangsu Wuzhong Nature Biotech Co.Ltd.,Nanjing 210097,China);Study on Antioxidant of Stropharia rugosoannulata Polysaccharide on Mouse Heart[J];Food Science;2007-09
2 WANG Yan,DONG Qun. Department of Microbiology and Immunology,Guangdong Medical College,Zhanjiang 524023,China;Effects of zuoguiyin and its partial prescriptions on cellular immune function in senile mice[J];Chinese Journal of Immunology;2006-09
3 PENG Xin-yan1,2,KONG Bao-hua2,XIONG You-ling3(1College of Food Engineering,Ludong University,Yantai 264025,Shandong,China;2College of Food Science,Northeast Agricultural University,Harbin 150030,China;3Department of Animal and Food Sciences,University of Kentucky,Lexington,Kentucky 40546,USA);Protective Effects of Whey Protein Isolate(WPI) Peptides on Lung Fibroblasts Cell MRC-5 Caused by the Damage of H_2O_2[J];Scientia Agricultura Sinica;2010-14
Chinese Journal Full-text Database 8 Hits
1 LIU Guo-sheng,LI Li,CHEN Guang-liang (Department of Integrated Traditional Chinese and Western Medicine, Anhui College of Traditional Chinese Medicine, Anhui Hefei 230038,China);Study on Anti-aging Effect of Bushen Granule[J];Journal of Anhui Traditional Chinese Medical College;2005-01
2 ZHU Qing Lei,XUE Qiao,MA Lu,et al (Institute of Geriatric Cardiology,Chinese PLA General Hospital,Beijing 100853,China);Changes in oxidative level and anti-oxidative ability in D-galactose induced senile rats[J];Editorial Department of Chinese Journal of Geriatric Cardiovascular and Cerebrovascular Disease;2002-06
3 ZHAO Xiangyuan, ZHANG Shiling, ZHEN Ming Nanjing Medical University Affiliated Brain Hospital, Najing,Jiangsu Province,210029\;;Aging Rat Model and Monoamine Neurotransmitters Change Induced by β-amyloid Protein[J];Journal of Brain and Nervous Diseases;2001-06
4 TAO Ming-xuan1,WANG Feng1,WANG Xiao-wei1,JIN Peng1,CHENG Guang-yu2,3(1.Jinling College,Nanjing Normal University,Nanjing 210097,China;2.School of Life Science,Nanjing Normal University,Nanjing 210097,China;3.Jiangsu Wuzhong Nature Biotech Co.Ltd.,Nanjing 210097,China);Study on Antioxidant of Stropharia rugosoannulata Polysaccharide on Mouse Heart[J];Food Science;2007-09
5 Yang jie,Zhu Qinglei,Yin Tong,et al.Institute of Geriatric Cardiology,General Hospital of PLA,Beijing 100853;Changes in oxidative level and anti-oxidative ability of principal tissues in D-galactose induced senile mice[J];Practical Geriatrics;2003-05
6 Wang Hui, Zhang Shuhua, Guo Aimin, Zhang Jinnan Department of Sanitary Chemistry, the Capital University of Medicine Science, Beijing 100054, China;Effects of almond on D-gal-induced aging rats[J];Journal of Hygiene Research;2004-02
7 Pan Jingqiang,Tan Hairong,Li Boping 1,Xiao Liuying,Han Chao (Guangzhou Institute of Traditional Chinese Medicine and Materia Medica,Guangzhou 510130; 1Guangzhou Hospital of Traditional Chinese Medicine,Guangzhou 510130);The progress of traditional chinese medicine on inhibiting D-galactose-induced pathologic animal model[J];Guangdong Pharmaceutical Journal;2001-05
8 La Yan, Liu Xiao-li, Pei Su-ping, Shi Yao Cai Dong-lian (Department of Clinical Nutrition, Changhai Hospital, Second Military Medical University, Shanghai 200433, China);Effect of Tremella Polysaccharides on the Immune Function of Experimental Aging Model Mice[J];Chinese Journal of Clinical Nutrition;2005-04
Chinese Journal Full-text Database 10 Hits
1 SHEN Ye-shou,TAO Wen-juan(School of Life Science, Anhui University, Hefei230039, China);Study on the application of fungus --fungus polysaccharides[J];Journal of Anhui University(Natural Sciences);2003-01
2 Ke Lixia(Department of Biology);The Nutritional Needs Of Flammulina Velutipes Under The Submerged Culture[J];Journal of Anhui Normal University(Natural Science);1994-02
3 SHEN Kan,SHAO Xue-ling,DEN Xiao-wei,YANG Qing-ping,XIAO Gen-fu (Experimental Centre of Basic Courses,College of Life Science,Wuhan University,Wuhan 430072);Effects of Pleurotus ostreatus Polysaccharide on Eliminating Super O_2~- and Peroxidation of Free Radical of Erythrocyte Membrane[J];Amino Acids & Biotic Resources;2002-02
4 NING Jing-ming,FANG Shi-hui,XIA Tao,ZHOU Tian-shan,LIU Jian(Key Laboratory of Tea Biochemistry & Biotechnology of Ministry of Agriculture,Anhui Agricultural University, Hefei 230036);Sterilization on Green Tea Drink by Microwave Technology[J];Journal of Anhui Agricultural University;2005-03
5 LI Shu-qian XIN Guang Department of Chemistry,Anshan Normal University,Anshan Liaoning 114007,China DAI Ya-dong Ansahn Horticulture Science Academe,Anshan Liaoning 114001,China LIU Chang-jiang Food College of Shenyang Agriculture University,Shenyang Liaoning 110161,China.;Study on Antioxidative Properties of Crude Polysaccharides from Fruit Body and Mycelium of Pleurutus Nebrodensis[J];Journal of Anshan Normal University;2007-02
6 LIN Wu-tao,NIAN Bao-yi ,WANG Zheng-min (Dept. Chem. & Biol. Engn., Sanming College, Sanming 365004,Fujian,China);Study on ultrasound fortified extracted polysaccharides from Agaricus Blazei Murill and mechanism[J];Journal of Baoji College of Arts and Science(Natural Science Edition);2004-03
7 ;Study on nutritional value of Auricularia Auricula[J];Journal of Jilin University of (Medicine Edition);2005-02
8 YUAN Gui-ying,SHI Ming-sheng,JIAO Lei(Henan Agricultural Vocation-technical College, Henan Agricultural University, Zhengzhou 451450,China);Research on Mushroom and White Fungus and Honeysuckle Healthy Yogurt Processing Technique[J];Storage and Process;2004-03
9 CAO Yu-lan,JIANG Tian-bao,LU Ze-jian (College of Food Science,Fujian Agriculture and Forestry University , Fuzhou 350002, China);Effects of Water Activity on Storage of Low-sugar Preserved Sinocolamus Latiflorus[J];Storage & Process;2006-03
10 Department of Nutrition and Food Hygiene Lin Xiaoming,et al;EFFECT OF TREMELLA, PORIA AND GYNOSTEMMA ON MURINE IMMUNOLOGICAL AND SCAVENGING FREE RADICALS FUNCTION[J];Journal of Beijing Medical University;1995-06
【Secondary References】
Chinese Journal Full-text Database 6 Hits
1 ZHAO Wei~(1,2),WEN Hai-xia~1,ZHENG Hui-li~3,SUN Shi-xiao~2,NI Jiang~(1#) (1 Department of Physiology,Harbin Medical University,Heilongjiang 150086;2 Department of Physiology,Heilongjiang University of Chinese Medicine;3 Department of Clinical Laboratories, Qiqihaer First Hospital);Effect and regulation of Zuogui Decoction on expression of ovarian P450 aromatase in rats during perimenopausal period[J];Journal of Beijing University of Traditional Chinese Medicine;2010-01
2 HOU Jun1,LIU Fang2,LI Le2,LIN Xiao-min1,DU Ai-ling1 (1.College of Forestry ,Henan University of Science Technology,Luoyang 471003,China; 2.Department of Microbiology,Nankai of University,Tianjin 300071,China );Research Progress on Antioxidant Components from Fungi[J];Food Science;2008-09
3 TAO Ming-xuan1,WANG Feng1,CHENG Guang-yu2,3,SHAN Yun1,JIN Bang-quan1(1.Ginling College,Nanjing Normal University,Nanjing 210097,China;2.School of Life Science,Nanjing Normal University,Nanjing 210097,China;3.Jiangsu Wuzhong Nature Biotechnology Co.Ltd.,Nanjing 210097,China);Antioxidation of Different Extracts of Edible Fungi on Blood and Kidney of Diabetic Mice[J];Food Science;2008-11
4 WANG Xiao-wei1,WANG Feng1,TAO Ming-xuan1,CHENG Guang-yu2,3,,XI Qing-li4,LU Zhong-ming4(1.Ginling College,Nanjing Normal University,Nanjing 21097,China;2.School of Life Science,Nanjing Normal University,Nanjing 210097,China;3.Jiangsu Wuzhong Nature Biotech Co. Ltd.,Nanjing 210097,China; 4.Jiangsu Centers for Diseases Prevention and Control,Nanjing 210093,China);Antioxidation of Stropharia rugoso-annulata Extract(SRE) on CC1_4-induced Acute Liver Injury in Mice[J];Food Science;2008-12
5 WANG Feng1,WANG Xiao-wei1,TAO Ming-xuan1,CHENG Guang-yu2,3,*,YANG Qi-yin2,NANG Xiao-xiao2 (1.Ginling College, Nanjing Normal University, Nanjing 210097, China ;2.School of Life Science, Nanjing Normal University, Nanjing 210097, China ;3. Jiangsu Wuzhong Nature Biotech Co. Ltd., Nanjing 210097, China);Free Radicals Scavenging Activity of Stropharia rugoso-annulata Polysaccharides and Their Protective Effects on D-galactose-induced Oxidative Damage of Mice[J];Food Science;2009-05
6 ZHAO Wei,WEN Hai-xia,ZHENG Hui-li,et al Department of Physiology,Harbin Medical University,Harbin (150086);Effect of Zuoguiyin on the Expression of Ovarian Follicle-stimulating Hormone Receptor in Rats during Peri-menopausal Period[J];Chinese Journal of Integrated Traditional and Western Medicine;2010-03
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved