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《Academic Journal of Second Military Medical University》 2004-12
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Transforming growth factor-β1 gene polymorphisms in Caucasians and Asians with post hepatitis fibrosis

WANG Hao,YANG Zai-Xing ,GAO Chun-Fang,WAN Mo-Bin,WANG Xiao-Jin,Senait Mengsteab, Axel M. Gressner,Ralf Weiskirchen4 (Department of Laboratory Medicine,Changzheng Hospital,Second Military Medical University, Shanghai 200003,China; Department of Infectious Diseases.Changhai Hospital,Second Military Medical University,Shanghai 200433; Department of Infectious Diseases,No. 85 Hospital of PLA,Shanghai 200031; Institute of Clinical Chemistry and Pathobiochemistry,RWTH University Hospital Aachen D52074,Germany)  
Objective:To study the association between polymorphisms at coding region of transforming growth factor-β1 (TGF-β1) gene and post hepatitis fibrosis in Caucasians and Asians. Methods: A novel approach for analyzing the polymorphisms of TGF-β1 gene was developed by combining real time fluorescence PCR and melting curve analysis in LightCycler system. Leu10Pro(TC),Arg25Pro(GC) and Thr26311e(OT) of TGF-β1 were analyzed with the above mentioned approach. The TGF-β1 genotypes were determined in Caucasians(210) and Asians(90) with post hepatitis fibrosis and the results were compared with those of 104 Asian normal controls and 50 Caucasian normal controls. Results: There was no gene polymorphisms at codon 25 and 263 in the Asian ancestry,which was significantly different from that of Caucasians. Meanwhile,in Asians the frequency of C at codon 10 was higher in patients with chronic hepatitis C infection(T/C =0. 444/0. 556) than in that of the controls(T/C = 0. 514/0. 486),but the difference was not statistically significant. In Caucasians,the frequencies of genetic variations at codon 10 and codon 25 in patients with chronic hepatitis C infection were closely associated with the progression of liver fibrosis (Average METAVIR-Scores). Conclusion: This study suggests that TGF-β1 polymorphisms are associated with fibrosis progression in hepatitis C in the Caucasians, while its association with liver fibrosis in Asians remains to be further confirmed.
【Fund】: 国家自然科学基金(30270605)
【CateGory Index】: R575.2
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【Secondary References】
Chinese Journal Full-text Database 2 Hits
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