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《Academic Journal of Second Military Medical University》 2005-08
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In vivo study of biocompatibility of chitin short fiber reinforced polycaprolactone composite

DUAN Liang 1,XU Zhi-fei 1*, SUN Kang 2 ,ZHAO Xue-wei 1, QIN Xiong 1,FANG Jia 2,GONG Zhi-yun 1 (1.Department of Cardiothoracic Surgery,Changzheng Hospital,Second Military Medical University,Shanghai 200003, China; 2.Institute of Composite Materials,Shanghai Jiaotong University,Shanghai 200030)  
Objective:To investigate the biocompatibility and biological safety of chitin short fiber reinforced polycaprolactone(PCL) composite in vivo so as to provide experimental reference for clinical application. Methods: Pure PCL and chitin short fiber reinforced PCL composite were immersed into 0.9% normal saline separately in order to obtain their extracts. Then the extracts were subjected to acute systemic toxicity test, hemolysis test, pyrogen test and sensitivity test. The 2 materials were implanted into the dorsal muscle of rabbits(n=6). The animals were killed 2, 4, 8, 12, 16 and 24 weeks after operation to observe the general condition of tissues and the morphology and thickness of the fibrous envelope. Results: There was no potential allergic substance in the chitin short fiber reinforced PCL composite, and no hemolytic reaction, acute systemic toxicity effect or pyrogen reaction was observed. Mild inflammatory reaction was seen in the surrounding tissues in the early implantation stage, which completely disappeared after 12 weeks. Macrophage aggregation was not noted. There was no significant difference in the biocompatibilities between pure PCL and chitin short fiber reinforced PCL composite. Conclusion: Chitin short fiber reinforced PCL composite has fine biocompatibility, which is feasible and safe for clinical reconstruction of chest wall defect.
【Fund】: 上海市科学技术发展基金(024419076).
【CateGory Index】: R318.08
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