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《Academic Journal of Second Military Medical University》 2006-07
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Pretreatment of sarsasapogenin in Rhizoma Anemarrhenae:a research of methodology

ZHU Dong-liang,LI Xiang,LOU Zi-yang,DONG Xin,CHAI Yi-feng~* (Department of Drug Analysis,School of Pharmacy Second Military Medical University,Shanghai 200433,China)  
Objective:To improve the pretreatment method described in ChP(2005 Edition,Vol Ⅰ) for the determination of sarsasapogenin in Rhizoma Anemarrhenae.Methods: According to orthogonal design L_(9)(3~(3)),the extraction time,alcohol concentration,extraction frequency,etc.were modified to achieve the best extraction outcome with ultrasonic wave extraction.Results: The optimal extraction condition included 70% alcohol and twice ultrasonic wave extraction,20 min each time.Finally hydrolization was applied to obtain sarsasapogenin for determination.Conclusion: Compared with the pretreatment method in ChP,this improved extraction method shows a higher sarsasapogenin content in determination and is more accurate in reflecting the true content of sarsasapogenin in Rhizoma Anemarrhene.
【Key Words】： Rhizoma Anemarrhene sarsasapogenin extraction
【Fund】： 上海市科委重大项目(2403DZ19548);; 上海市科委科技攻关项目(02419125)~~
【CateGory Index】： R284.2
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