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《Academic Journal of Second Military Medical University》 2006-10
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Effect of hyperbaric oxygen on an endothelin-1-induced focal cerebral ischemic model in rats

GU Guo-jun,HUANG Zhen-xing,TAO Kai-zhong,LIU Yun,TAO Heng-yi,PENG Zhao-yun,SUN Xue-jun~*(Department of Diving Medicine,Faculty of Navy Medicine, Second Military Medical University,Shanghai 200433,China)  
Objective:To establish a focal cerebral ischemia/reperfusion(FCI/R) model with endothelin-1(ET-1) in rats and to observe the effectiveness of hyperbaric oxygen(HBO) in treatment of this model.Methods: Three μl ET-1(60 pmol per μl) was injected into the site adjacent to rat middle cerebral artery(MCA) under anesthesia to induce FCI/R model.HBO(100% O_(2),2.5 ATA for 2 h) was applied at 1 h after ET-1 injection in ET-1+HBO group;rats in FCI/R model group received no treatment.Neurological scores were determined at 4 h,8 h,and 24 h after injection.Animals were all killed at 24 h to harvest brain tissues for water content assessment and TTC,H-E staining.Results: ET-1 had a high successful rate in inducing FCI/R model in rats,with stable infraction area and good repeatability.Animals in ET-1+HBO group had better neurological outcomes than controls at all the 3 time points(P0.05 at 4 h and 8 h,P0.01 at 24 h).HBO treatment significantly decreased the brain water content(P0.01),reduced the infarction areas(P0.05),and obviously alleviated the cerebral lesions as showed by H-E staining.Conclusion: The ET-1-induced FCI/R model provides an ideal model for studying human cerebral ischemia diseases.HBO(100% O_(2),2.5 ATA for 2 h) treatment administrated 1 h after focal cerebral ischemia can improve the neurological outcomes of the model animals,reduce the infarction areas,and alleviate ischemic brain lesion.
【Fund】: 国家自然科学基金面上项目(30500579).~~
【CateGory Index】: R743
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1 MEI He Shan ,SU Su Wen, WANG Yong Li,LI Hai Fang (Dept of Pharmacology,Hebei Medical University,Shijiazhuang 050017);The focal cerebral ischemia and reperfusion model induced by Endothelin-1 in rat[J];Chinese Pharmacological Bulletin;2004-01
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