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《Academic Journal of Second Military Medical University》 2007-07
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Comparison of electret and chemical enhancers in enhancing transdermal delivery of meloxicam

HOU Xue-mei1,CUI Li-li1,JIANG Jian2,LI Guo-dong 1,LIANG Yuan-yuan2,SONG Mao-hai 2,KONG Yu-xiu1,CHENG Liang 2(1.Department of Inorganic Chemistry,School of Pharmacy,Second Military Medical University,Shanghai 200433,China;2.Department of Physics and Mathematics,College of Basic Medical Sciences,Second Military Medical University,Shanghai 200433)  
Objective:To compare the effects of electret and chemical enhancers in enhancing the transdermal delivery of meloxicam.Methods:The study was divided into 4 groups,including meloxicam patch group(control),chemical enhancer + meloxicam patch group,electret meloxicam patch,and electret + chemical enhancer + meloxicam patch group.The in vitro skin permeation of meloxicam from patches was examined by using a modified Franz diffusion cell.Ultraviolet spectrophotometry(362 nm)was used to analyze the drug concentration in the receptor.The 10 h-cumulated permeation amount of meloxicam from patchs was calculated in 3 experimental groups and were compared with that the control group.The enhancing abilities of electret and chemical enhancers were compared and the synergistic effect of them was assessed.Results:(1)1%,3% and 5% azones showed 1.20,1.33,and 1.26 fold-increases in the 10 h-cumulated permeation of meloxiam respectively as compared with control group(P0.05).(2)Most of the chemical enhancers used in this study(1%,3% and 5% azones,10% ethyl oleate,1% menthnol,and 30% sulphoxiade),except for 20% propylene glycol,had enhancing effect on transdermal delivery of melocicam.Ethyl oleate(10%)was proven to be the most potent enhancer,showing a 1.86-fold cumulated permeation that of the control group(P0.05);(3)Electret was more potent than the chemical enhancers in promoting meloxicam transdermal delivery,showing a 2.16-fold cumulated permeation that of control group(P0.05);(4)Electret improved the enhancing effect of chemical enhancers in this study.The cumulated permeation of meloxicam in electret + chemical enhancer + meloxicam patch group was 1.14-2.82 folds that of the chemical enhancer + meloxicam patch group(P0.05).Conclusion:Electret has a good promoting effect for transdermal drug delivery and can be used as a novel enhancer in transdermal delivery of drugs.
【Fund】: 国家自然科学基金(50577066);; 军队“十一五”科技攻关项目(06H022).~~
【CateGory Index】: R94
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