Study on chemical constituents of Duchesnea indica Andr.Focke

MIAO Qing1,2,BAO Hai-yan1,2,PIAO Shu-juan1,LIN Hou-wen1*,QIU Feng21.Department of Pharmacy,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China2.Department of Natural Medicinal Chemistry,School of Chinese Materia Medica,Shenyang Pharmaceutical University,Shenyang 110016  

Objective:To investigate the chemical constituents in the EtOAc fraction of the EtOH extract of Duchesnea indica Andr.Focke.Methods:Extraction was done with 95% EtOH.EtOAc fraction of the EtOH extract was isolated and purified by column chromatography using silica gel,RP-C18,Sephadex LH-20 and HPLC.The structures of the compounds were identified by their physico-chemical properties and spectral analysis.Results:Thirteen compounds were obtained from the EtOAc fraction of Duchesnea indica Andr.Focke and they were identified as euscaphic acid(1),arjunic acid(2),p-hydroxy cinnamic acid(3),apigenin(4),kaempferol(5),2α-hydroxy ursolic acid(6),2α-hydroxy oleanolic acid(7),tomentic acid(8),kaii-ichigeside F1(9),potengriffioside A(10),rosamultin(11),kaempferol-3-O-β-D-glucoside(12),and isoquercitrin(13).Conclusion:The compounds 2-5,10,and 12 have been isolated from the genus of Duchesnea for the first time.

【Key Words】： Duchesnea indica isolation and purification TCD identification apigenin potengriffioside A
【CateGory Index】： R284.1
【DOI】： CNKI:SUN:DEJD.0.2008-11-026

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