Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Academic Journal of Second Military Medical University》 2010-09
Add to Favorite Get Latest Update

A comparative study of diet-induced obesity and diet-induced obesity-resistant non-alcoholic fatty liver in rats

WANG Ying1,CAI Dong-lian1 ,WANG Hong2,HUANG Ying3,ZHANG Lei1 1. Department of Nutriology,Changhai Hospital,Second Military Medical University,Shanghai 200433,China 2. Department of Clinical Nursing,No. 461 Hospital of PLA,Changchun 130021,Jilin,China 3. Department of Cardiology,Changhai Hospital,Second Military Medical University,Shanghai 200433,China  
Objective To observe the changes of non-alcoholic fatty liver related indices in diet-induced obesity-resistant rats and diet-induced obesity rats. Methods A total of 140 male Sprague Dawley( SD) rats were randomly divided into normal control group ( n = 20,normal diet for 8 weeks) and model group ( n = 120,high fat diet for 8 weeks). The rats of model group were further divided into 2 groups:O -N ( obesity with non-alcoholic fatty liver) and OR-N ( obesity-resistance with non-alcoholic fatty liver) groups. The rats with body mass higher than mean + 1. 96 folds standard deviation were included in O-N group and those with body mass lower than mean + 1. 0 fold standard deviation were included in OR-N group. The animals with the top 20 weight gains in the O-N group and those with the least 20 weight gains in OR-N group were used in the present study. The general conditions and weight changes of rats were dynamically observed for 8 weeks. Eight rats were sacrificed in each group at the end of the 8th week and the following indices were compared among the three groups,including serum levels of alanine aminotransferase ( ALT) ,total cholesterol ( TC) ,triglyceride( TG) ,high-density lipoprotein ( HDL) ,insulin sensitivity index( ISI) ,leptin,energy utilization and body fat ratio. The pathological changes of liver tissues were observed by H-E staining. Results The weight difference of rats in the O-N group and the OR-N group gradually increased; at the end of the 8th week,the weight of rats in O-N group was significantly higher than those in the OR -N group and the normal control group( P 0. 01). The serum levels of ALT,TG,and leptin were significantly increased in both O-N and OR -N groups ( P 0. 05,P 0. 01). The TC,TG,leptin levels and energy utilization in O-N group were significantly higher than those in OR -N group ( P 0. 05,P 0. 01). The HDL and ISI levels in the O-N group were significantly lower than those in the OR-N and normal control groups ( P 0. 01,P 0. 05). Light microscopy showed a great number of fat vacuoles in the liver cells of O-N and OR-N groups. Conclusion High fat diets can induce SD rat to develop non-alcoholic fatty liver with obesity and obesity-resistance. Increase in serum leptin and ISI may play a role in resisting diet-induced obesity and non-alcoholic fatty liver of rats.
【CateGory Index】: R589.25
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 5 Hits
1 LI Yun-hong,XU Zhao-min,LU Ying,HUANG Qun,ZOU Xiao-ping (Department of Gastroenterology,the Affiliated Drum Tower Hospital of Nanjing University Medical School,Nanjing 210008,China);The study of the relationship between insulin resistance and nonalcoholic fatty liver disease[J];Acta Universitatis Medicinalis Nanjing(Natural Science);2008-06
2 Wang Chongjian,Yang Nianhong △,Xu Mingjia et al Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030;Different Susceptibility to High-fat Diet Induced Obesity in Rats[J];Acta Universitatis Medictnae Tangji;2005-01
3 WANG Shu-ran,MA Wei-wei,ZHAO Dan,et al.Department of Nutrition and Food Hygiene,College of Public Health,Harbin Medical University(Harbin 150081,China);Establishment of obesity prone and obesity resistant rats induced by high-fat diet[J];Chinese Journal of Public Health;2007-07
4 FAN Jian-gao, ZHU Jun, LI Xin-jian, LI Rui, DAI Fei, SONG Xiao-min, CHEN Lan, LI Feng, CHEN Shi-yao. Fatty Liver Research Center, Shanghai First People's Hospital, Jiaotong University, Shanghai 200080, China;Epidemiological survey of prevalence of fatty liver and its risk factors in a genera] adult population of Shanghai[J];Chinese Journal of Hepatology;2005-02
5 YAN Cai-feng,XIANG Hong-ding,PING Fan,et al.Department of Endocrinology,Peking Union Medical College,Beijing 100730,China;The Relationship between the Different Types of Non-alcoholic Fatty Liver Disease and Glucose and Lipid Metabolism[J];Chinese Journal of Prevention and Control of Chronic Non-Communicable Diseases;2006-05
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 SONG Yu-lin,ZHU Zhen,XU Jian-ming,PAN Min (Dept of Gastroenterology,The First Affiliated Hospital of Anhui Medical University,The Key Laboratory of Digestive Disease of Anhui Province,Hefei 230022);Fatty liver prevalence in the 1277 cases of hospital employees and its correlation with hyperlipidemia[J];Anhui Medical and Pharmaceutical Journal;2008-09
2 ZHAO Wen-xia1,LI Hong-de2(1The First Affiliated Hospital of Henan College of TCM,Zhengzhou 450000,China;22005 Grade Post-graduate of Henan College of TCM,Zhengzhou 450008,China);Role of CT in diagnosis and treatment of non-alcoholic fatty liver by TCM[J];China Journal of Traditional Chinese Medicine and Pharmacy;2008-12
3 CHENG Chao-ying, LU Xian-e, ZHONG Zhao-hui ,et al. (1.The 8th People′s Hospital,Chongqing 400015,China;2.Department of Epidemiology,Chongqing University of Medical Sciences,Chongqing 400016,China;3.the Third People′s Hiospital of Fuling District of Chongqing,Chongqing 408100,China;4.Hiospital of Chang′an Factory,Chongqing 400023,China);Epidemiological investigation and analysis of fatty liver in different occupations in Chongqing[J];Chongqing Medical Journal;2005-12
4 LI Xiang,LI Xiao-ping,HE Yan,LIU Chao-yong(Department of Ultrasonography,Lushan Sanatorium of Nanjing Military Command,Jiujiang 332000,Jiangxi,China);Investigation of relationship between incidence of sanatorium fatty liver and cognizance of fatty liver risk factor[J];Journal of Southeast China National Defence Medical Science;2006-05
5 ZHANG Weiwei1),DU Bing1),LUO Kewen1),LIN Junling2),LI Hong1).1)Beijing Health Examination Center,Beijing 100045,Beijing;2)Jingxi District,Beijing Chaoyang Hospital of Capital Medical University;Analysis of the incidence and relevant factors of fatty liver in health examination subjects[J];Clinical Medicine;2008-05
6 Chen Yanxi,Yu Xinsen,Jiang Jianhua,et al.Municipal Center of Disease Control,Haimen City,Jiangsu,226100;The prevalence of fatty liver in individuals in suburbs of Haimen city[J];Journal of Clinical Hepatology;2006-01
7 WANG Yongbing,SONG Hongjie,WANG Wuyun,et al.People's Hospital,Haimen,Jiangsu,226100;Prevalence and risk factors of fatty liver in HaiMen area in individuals on physical examination[J];Journal of Clinical Hepatology;2006-06
8 LIN Su,CHEN Jing,DONG Jing,et al. Liver Research Center,The First Affiliated Hospital,Fujian Mdedical University,Fuzhou 350005;The prevalence of non-alcoholic fatty liver disease in patients with hypothyroidism[J];Journal of Clinical Hepatology;2009-04
9 (SHI Xiao-min,FU Zhi-ren,DING Guo-shan,et al.Organ Transplantation Institute of PLA.Affiliated Changzheng Hospital, Second Miliatary Medical University,Shanghai 200003,China.);RAPID EVALUATION OF QUALITY OF LIVER AND PERFUSION AT THE LIVER GRAFT HARVESTING[J];Journal of Hepatobiliary Surgery;2005-03
10 Wu Qi-kai~1,Cheng Jing-jun~2,Nie Guang~1,et al.1.Department of Integrative Medicine,Shenzhen East Lake Hospital(Shenzhen,518020) China; 2.Hubei College of Traditional Chinese Medicine(Wuhan,430061);A Clinical Research on the Therapeutical Effect of Zhiyanxiao Decoction on 63 Cases with Nonalcohlic Fatty Liver[J];Guangming Journal of Chinese Medicine;2007-02
China Proceedings of conference Full-text Database 5 Hits
1 Li Li Bo Qingli Zou Li Wang Sufang Ruan Liang Sun Yehuan (School of Public Health,Anhui Medical University,Hefei,230032);Body Mass index,Blood lipids,Fasting glucose,Blood pressure and Fatty liver Risk:a Meta-analysis[A];[C];2007
2 Wang Chongjian Yang Nianhong Hao Liping Nie Shaofa (School of Public Health,Tongji Medical college,Huazhong University of Science & Technology,Wuhan,430030);Relation between appetite-regulating hormones and obesity susceptibility in rats[A];[C];2007
3 ;Epidemiological survey of Prevalence of fatty liver and its risk factors in population of Wenzhou who Subject to health check-up[A];[C];2009
4 LIU Xiao-qing,LI Hui,LIN Zhi-jian,ZHUANG Hong-yan,ZHANG Bing (Beijing University of Chinese Medicine,Beijing 100029);Study of dependability between hypertriglyceridemia and the formation of abdominal obesity on high fructose diet induced rat model[A];[C];2009
5 LAN Ian,ZHU Cai-zhong,ZHANG Hong-jun,et al.Department of Epidumiology,the Third Military Medical University,Chongqing 400038,China;Comprehensive Evaluation of Influencing Factors on Fatty Liver Disease in China:A Systematic Review[A];[C];2009
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 Liu Liming Institute of Child & Adolescent Health;EXPERIMENTAL STUDY OF DIETARY OBESITY IN RAT INDUCED BY HIGH FAT DIET[J];;1991-05
2 ZHAO Fei,WANG Yu-wei,LIU Xin-jie,YANG Jie.(Department of Pediatrics,Qilu Hospital,Shandong University,Jinan,Shandong 250012,China);Effect of high-fat-diet on serum glucose,triglyceride,leptin and insulin sensitivity in obesity-susceptible and obesity-resistant rats.[J];Chinese Journal of Child Health Care;2004-06
3 Chen Jing, Tian Zhiqiang, Luo Zhidan et al. Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing 400042, China;Relationships between the distribution of abdominal adipose tissue and the components of metabolic syndrome[J];Medical Journal of Chinese People's Liberation Army;2005-08
4 WANG Zhongli,XIA Bing,CHEN Xiangqun,et al.Department of Internal Medicine & Geriatrics,Wuhan University Zhongnan Hospital,Wuhan 430071,China;Hypoadiponectinemia is associated with Non-alcoholic fatty liver disease and metabolic syndrome[J];Journal of Clinical Internal Medicine;2007-09
5 Fan Jiangao,Zeng Mingde,Chen Zhengjie, et al.Shanghai Institute of Digestive Disease,Renji H ospital,Shanghai Second Medical University ,Shanghai,2 0 0 0 0 1.;Analysis of etiology and characteristics of fatty liver in2 6 5 patients[J];Shanghai Medical Journal;1998-02
6 WANG Tianyou,ZHAN Yutao,LIU Bin,XIN ZhongDepartment of Gastroenterology,Beijing Tongren Hospital,Capital University of Medical Sciences,Beijing 100730,China;A clinic study of fatty liver in patients with type 2 diabetes mellitus[J];Chinese Journal of Gastroenterology and Hepatology;2007-02
7 WANG Chong-jian, YANG Nian-hong, XU Ming-jia, LIU Lie-gang, SUN Xiu-fa. (Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030,China);HYPOTHALAMIC NEUROPEPTIDE Y AND ITS RECEPTORS mRNA EXPRESSION IN DIET-INDUCED OBESE AND RESISTANT RATS[J];Acta Nutrimenta Sinica;2006-02
8 ZHENG Linlin,YAO Xingjia,WU Hui,et al.Department of Child and Adolescent Health,College of Public Health,China Medical University(Shenyang 110001,China);Study on change of GH/IGF-I axis in diet-induced male obese rats[J];China Public Health;2005-03
9 WANG Kun,AO Youte,ZHAO Lei,et al.Department of Cardiology,the First Affiliated Hospital of Xinjiang Medical University(Urumqi 830054,China);Analysis on obesity and its risk factors among inhabitants of Bortala prefecture of Xinjiang autonomous region[J];Chinese Journal of Public Health;2006-09
10 WANG Jing-han,SU Li,WANG Zhong-xin,ZHANG Fan.Department of Endocrinology,First Affiliated Hospital,Fujian Medical University,Fuzhou 350005,China;Waist Circumference is The Most Important Components of Metabolic Syndrome[J];Chinese Journal of Hypertension;2007-11
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved