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《Academic Journal of Second Military Medical University》 2010-10
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β-amyloid and Alzheimer disease:recent progress

LI Tuo,ZHAO Zhong-xin Department of Neurology,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China  
Alzheimer disease(AD)is the most common form of dementia in aged population;it is a neurodegenerative disorder with unknown etiology and pathogenesis.The major pathological findings of AD include senile plaques,neurofibrillay tangles,and apoptosis-related regional synaptic and neuronal degeneration.The brain senile plaques are mainly produced by β-amyloid,apeptide with neurotoxicity and vasculotoxicity.Due to the polygenic and heterogeneous characteristics of AD, Amyloid Cascaded Hypothesis is currently drawing increasingly more attention.This paper reviews the relation between Aβand AD published recently.
【Fund】: 上海市科技发展基金(08411950700)~~
【CateGory Index】: R749.16
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Chinese Journal Full-text Database 3 Hits
1 LIN Xu1,HUANG Ai-ling2,HONG An-hui3,LU Tun2(1.Fujian Food and Drug Administration Information Center,Fuzhou 350003,China;2.College of Biological Science and Technology,Fuzhou 350108,China;3.The People's Hospital of Tai Shan City,TaiShan 529200,China);Study of Anti-Aβ drug therapy of Alzheimer's disease[J];Strait Pharmaceutical Journal;2008-10
2 ZHAO Tingting1,2,ZHANG Quanbin2,ZHANG Zhongshan2,WANG Jing2,LI Zhi'en2,XU Zuhong2(1.Pharmacological Laboratory,China-Japan Friendship Institute of Clinical Medical Sciences,Beijing 100029,China;2.Institute of Oceanology,Chinese Academy of Sciences,Qingdao 266071,China);Effect of Fucoidan on Cognitive Ability and Cerebral Cholinergic System in Mice with Alzheimer's Disease[J];Traditional Chinese Drug Research & Clinical Pharmacology;2010-02
3 Liu Zhi-an1,2,Zhao Wei-wei3,Ma Kai4,Lü Chun-e2,Xu Tie-jun1,21Jiangsu Province Key Laboratory of Brain Disease Bioinformation,2Department of Anatomy and Neurobiology,4Department of Computer,Xuzhou Medical College,Xuzhou 221002,Jiangsu Province,China;3Department of Radiology,Affiliated Xijing Hospital of Fourth Military Medical University,Xi'an 710032,Shaanxi Province,China;Establishment of a Alzheimer's disease rat model intervened by beta-amyloid protein 1-40 and aluminum chloride[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2010-37
【Secondary Citations】
Chinese Journal Full-text Database 6 Hits
1 FANG Fang ,YAN Yong ,FENG Zhan-hui ,et al. (Department of Neurology ,First Affaliated Hospital,Chongqing University of Medical Sciences,Key Laboratory of Neurology in Chongqing ,Chongqing 400016,China);Study of Alzheimier's disease animal model induced by multiple factors[J];Chongqing Medicine;2007-02
2 Luo Xiumei, Long Dahong, Pan Xuebing, Yang Dandi, Xuan Aiguo, Li Jiamei (Department of Anatomy, Guangzhou Medical College, Guangzhou 510182);THE STUDY ON DEMENTIA MODELS INDUCED BY INTRACEREBROVENTRICULAR INFUSION OF 192-IgG-SAPORIN[J];Chinese Journal of Neuroanatomy;2006-06
3 CHU Jin, LI Lin (Dept of Pharmacology, Xuan Wu Hospital of Capital University of Medical Sciences, Beijing 100053,China);The dementia models induced by intracerebroventricular infusion of β-Amyloid peptide in mice[J];Chinese Pharmacological Bulletin;2004-07
4 GAO Bo~1,YAO Chun-suo~1,ZHOU Jin-yun~1,CHEN Ruo-yun~1,FANG Wei-shuo~(1,2*)(1.Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine,Ministry of Education,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China;2.College of Pharmacy,Wuhan University,Wuhan 430072, China);Active constituents from Aloe arborescens as BACE inhibitors[J];Acta Pharmaceutica Sinica;2006-10
5 Zhang Xiaojie, Niu Yingcai ,Zhou Li , Li Pengtao~1 (Qiqihar Medical College, Qiqihar 161042; Beijing University of Traditional Chinese Medicine, Beijing 100102);Expression of BACE1 mRNA in Aβ1-40 induced AD in rats and the effect of TLJN Oral Solution (通络救脑口服液)[J];Pharmacology and Clinics of Chinese Materia Medica;2006-06
6 Yang Xiaojuan,Zhang Shenglin,Chen Yun,et al Shanxi Medical University (Taiyuan 030001);A Novel Complex Animal Model of Aged Dementia[J];Chinese Journal of Integrative Medicine on Cardio-/Cerebrovascular Disease;2006-04
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