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《Academic Journal of Second Military Medical University》 2010-10
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β-amyloid and Alzheimer disease:recent progress

LI Tuo,ZHAO Zhong-xin Department of Neurology,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China  
Alzheimer disease(AD)is the most common form of dementia in aged population;it is a neurodegenerative disorder with unknown etiology and pathogenesis.The major pathological findings of AD include senile plaques,neurofibrillay tangles,and apoptosis-related regional synaptic and neuronal degeneration.The brain senile plaques are mainly produced by β-amyloid,apeptide with neurotoxicity and vasculotoxicity.Due to the polygenic and heterogeneous characteristics of AD, Amyloid Cascaded Hypothesis is currently drawing increasingly more attention.This paper reviews the relation between Aβand AD published recently.
【Fund】: 上海市科技发展基金(08411950700)~~
【CateGory Index】: R749.16
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【Co-citations】
Chinese Journal Full-text Database 3 Hits
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