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《ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY》 1994-04
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Studies on Hyaluronate in Carbon Tetrachloride Induced Cirrhotic Rat Liver

Gao Feng;Cao Manlin;Kong Xiantao(Center of Clinical Immunology,Changzheng Hospital,Second Military Medical University,Shanghai,200003)  
Liver cirrhosis was induced in rats with carbon tetrachloride.Hyaluronate(HA)levels were measured in both serum and liver homogenate using ELISA.The results demonstrated a significant increase of serum HA levels that occurred early and in the late stage of liver fibrosis.The serum concentrations of HA in different stages paralleled the progressed liver damage.In contrast, no significant increase was seen in the liver homogenate level of HA in the early stage of liver fibrosis, but occurred in the late stage.The results suggest that immunoassay for HA in serum is a more sensitive index for liver cell damage and hepatic fibrosis.
【CateGory Index】: R575.202
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