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《ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY》 1995-04
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Inhibitory effect of piperbetol,methyl piperbetol,piperol A and piperol B on rabbit platelet aggregation in vitro

Zeng Huawu; Jiang Yuanying; Long Kun; Chen Zhongliang (Department of Pharmacology,College of Pharmacy, Second Military Medical University, Shanghai, 200433)  
Piperbetol, methyl piperbetol, piperol A and piperol B inhibited the aggregation of rabbit platelet induced by PAF and the IC_(50) values were 17.9, 9.2, 142.0 and 14.0 μmol·L ̄(-1), respectively.Methyl piperbetol and piperol B also inhibited the aggregation of washed rabbit platelet pretreated with ASA and CP/CPK induced by PAF, and the IC_(50) values were 9.0 and 16.5 μmlo·L ̄(-1), respectively. But the four compounds had little inhibitory effect on rabbit platelet aggregation induced by ADP and AA.Piperol B caused a right shift in PAF concentration-response curve of platelet aggregation, and the EC_(50) was increased from 1.5 to 20.6 mol·L ̄(-1). These results suggest that the four compounds have selective inhibitory effect on rabbit platelet aggregation induced by PAF.
【CateGory Index】: R695.1
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1 YU Rui XIAO Fei LI Xiao-guang LUO Huan-min (Neuropharmacological Research Laboratory,College of Pharmacy,Jinan University,Guangzhou 510632,China);Inhibition of liposoluble extracts from Quchiling on M146L cell-secreted amyloid beta-proteins[J];中国新药杂志;2006-13
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4 Zeng Huawu; Jiang Yuanying; Long Kun; Chen Zhongliang (Department of Pharmacology,College of Pharmacy, Second Military Medical University, Shanghai, 200433);Inhibitory effect of piperbetol,methyl piperbetol,piperol A and piperol B on rabbit platelet aggregation in vitro[J];第二军医大学学报;1995-04
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1 WEI Bin;JIANG Xiao-li;ZHANG Jian-hong;SHEN Deng-feng;Ningbo Agriculture Science Academy;;Research Progress of Pharmacological Effects and Cultivation Process Technology of Scrophularia ningpoensis Hemsl.[J];安徽农业科学;2017-28
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