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《ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY》 1995-04
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The inhibitory effects of some Chinese herbs or its components on albumin nonenzymatic glycosylation

Ge Yong; Zhang Jiaqing; Zhou Yunping (Department of Endocrinology,Changhai Hospital,Second Military Medical University, Shanghai, 200433)  
In an albumin glycating system in vitro,we found that the amount of albumin AGE has a definite relationship with glucose concentration, temperature and time. In 37℃ glucose concentration 200 mmol/L system, 4 weeks are enough to make a significant AGE elevation, but in 37℃ glucose concentration 100 mmol/L system, 12 weeks are needed. So we prefer 37℃ glucose concentration 200 mmol/L system to screen drugs. In this study, quercetin and silybin exhibited some inhibitory activities on albumin nonenzymatic glycosylation in vitro. Their IC_(50) values for AGE were 5.44×10 ̄(-5) and 7.30×10 ̄(-6) mol/L,for brown products were 2.36×10 ̄(-6) and 4.27×10 ̄(-6) mol/L, respectively.
【CateGory Index】: R285.5
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