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《ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY》 1995-04
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Effects of icariine on lymphocyte proliferation and production of colony stimulating factor-like activity from mice splenocytes in vitro

Li Shutong; Li Tiejun; Zheng Qinyue; Wang Hongbin (Department of Pharmacology, College of Pharmacy, Second Military Medical University, Shanghai,200433)  
To investigate the effects of icariine (ICA)on immumo-system,we observed the influence of ICA on concanavalin A (Con A)-primed murine spleen lymphocyte proliferation and colony stimulating factor (CSF)-like activity produced by Con A or lipopolysaccharides(LPS)-primed murine spleen lymphocytes by way of [3H]-TdR incorporation and bone marrow cells [3H]-TdR incorporation seperately. The results showed that ICA could significantly enhance Con A-induced mice lymphocyte proliferation in vitro; increased CSF-like activity was detected in the supernatant of Con A-primed mice lymphocyte culture after ICA was added to the culture. These results suggest that ICA can augment immunologic function and enhance hematopoiesis.
【Key Words】： icarrin concanavalin A lipopolysaccharides lymphocyte colony stimulating factor mice
【CateGory Index】： R285.5
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