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《ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY》 1995-06
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Effects of icarrin on function of murine peritoneal macrophages

Li Shutong;Li Tiejun;Zheng Qinyue;Wang Hongbin(Department of Pharmacology,College of Pharmacy,Second Military Medical University,Shanghai,200433)  
Effects of icarrin(ICA)on the function of murine macrophages were investigated in ICR mice experiment.The results showed that ICA 0.01 ̄1 μ/ml could significantly augment M phagocytic activity.The M phagocytic activity was measured by the quantity of phagocytic neutrol red.We also found that ICA(0.001 ̄10 μg/ml) could dose-dependently increase the production of interleukin-1 (IL-1) and tumor necrosis factor (TNF) from LPS(10 μg/ml) treated M.These results suggest that ICA can activate M and may regulate murine immune functions.
【Key Words】: macrophages icarrin neutrol red interleukin-1 tumor necrosis factor mice
【CateGory Index】: R285.5
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