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《ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY》 1996-03
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Effects of Piperol B on transmembrane metabolism and biosynthesis of PAF in rabbit platelets

Zeng Huawu;Jiang Yuanying;Long Kun;Liu Mingzhu(Center of Drug Research, Navy 411Hospital, Teaching Hospital of Second Military Medical University, Shanghai, 200081)  
To look into the relationship between anti-activating of rabbit platelets of Piperol B and its effect on the transmembrane metabolism and biosynthesis of platelet-activating factor(PAF) in rabbit platelets. Methods: Using radioactive thin-layer chromatography and bioassay of PAF, we studied the effect of Piperol B on the transmembrane metabolism and biosynthesis of PAF in rabbit platelets. Results: Piperol B and Ginkgolide B(BN52021) could inhibit the metabolism of [3H]-PAF in rabbit platelets, IC50s were 84.8 , 34.9μmol· L-1, respectively. Piperol B(10, 50μmol·L-1) had no effect on the biosynthesis of PAF stimulated by A23187. High concentration of Piperol B (100μmol·L-1)had low inhibition of PAF production, and the inhibition was 16.3 %. Conclusion: The anti-activating effect of Piperol B was attributed to its inhibition of Piperol B of transmetabolism of PAF.
【CateGory Index】: R965.3
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