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《ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY》 1997-04
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The changes of psychological stress induced behaviors, plasma corticosterone and levels of amino acids at brain regions in rats

Yan Jin, Wang Chunan, Chen Yizhang, Xu Renbao (Department of Biology, Department of Basic Medicine, Second Military Medical University, Shanghai, 200433)  
Objective: To investigate the changes of psychological stress induced behaviors, plasma corticosterone and levels of amino acids in visual cortex, hippocampus, hypothalamus and cerebellum. Methods: A model of psychological stress was established with conditioned reflex (light shock). The open field test, radioligand protein binding and amino acids autoanalysis were used in this study. Results: During combined stresses, the levels of glutamate (Glu) and gamma aminobutyric acid(GABA) in visual cortex were changed and horizontal and vertical behaviors were increased. And during psychological stress, changes of the levels of Glu, GABA and taurine (Tau) occurred in visual cortex, hippocampus, hypothalamus and cerebellum, especially hippocampus, and behaviors were decreased. Conclusion: During psychological stress, the changes of Glu, GABA and Tau levels at brain regions may be relative to stress induced depressive behaviors.
【Key Words】: psychological stress corticosterone amino acid
【Fund】: 军队医药科研基金“八五”规划指令性课题
【CateGory Index】: R395.2
【DOI】: cnki:ISSN:0258-879X.0.1997-04-014
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