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《ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY》 1998-01
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The changes in insulin and insulin receptor after brain injury in rats

Lu Hongshe, Su Bo, Zhu Cheng, Zhang Guangji, Jiang Jiyao (Department of Oncology,Changhai Hospital, Second Military Medical University, Shanghai,200433)  
Objective: To study the changes in blood insulin and insulin receptor(IR) binding rates of RBC in rats after brain injury(BI). Methods: Eighty male rats were divided into 4 groups, including 3 groups of BI(light, medium, severe) and control group. All rats were killed 6,24 and 72 h after BI and their blood insulin and IR binding rates were determined. Results: The IR binding rates of RBC in rats increased markedly in the light and medium groups, but decreased markedly in the severe one. The IR binding rates of RBC in rats increased markedly in all groups at 24 h , and decreased markedly in the severe groups at 72 h after BI. The blood insulin increased markedly in the medium group and only little changes occurred in the light and severe groups. No differences of insulin was observed in the light group but it highly increased in the medium and severe groups at 24 h after BI. Blood insulin decreased markedly at 72 h in the severe group. Conclusion: The high level of blood sugar is probably caused by decreased insulin activities but not by decreased blood insulin contents and IR on cell membrane.
【Fund】: 军队“八五”医药科研规划课题
【CateGory Index】: R651.15
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