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Role of calcitonin gene related peptide during the development of rat gastric stress ulceration

Lei Yinxue, Li Zhaoshen, Zhan Xianbao, Xu Guoming (Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, 200433)  
Objective: To evaluate the role of calcitonin gene related peptide (CGRP) in plasma of rats after cold restraint stress. Methods: The contents of CGRP in plasma of rats were assessed with RIA before and 2,4,6,8 h after stress. The contents of CGRP in plasma, GMBF, gastric ulcer index and pH of gastric juice were measured 2 h after cold restraint stress in different groups, which were pretreated with indomathacin (5 mg/kg, sc), L NAME (5 mg/kg, iv) and saline (5 ml/kg, iv). Results: The content of CGRP in plasma rose 6 and 8 h after stress. Compared with control, the content of CGRP in plasma and gastric ulcer index increased, whereas GMBF decreased in groups pretreated with L NAME or indomethacin; pH of gastric juice had no change. Conclusion: CGRP releasing increases compensatively with serious gastric mucosa lesion after cold restraint stress in rats. Administration of L NAME and indomethacin before stress exacerbates the gastric mucosa lesion and stimulates the releasing of CGRP.
【Fund】: 全军医药卫生杰出中青年人才基金
【CateGory Index】: R364.16,
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