CONDITIONS AND FACTORS AFFECTING THE DEVELOPMENT OF OSTEOMALACIC SKELETAL FLUOROSIS. AN EXPERIMENTAL STUDY
Li Guang-sheng, et al (Institute of Endemic Diseases, Norman Bethune University of Medical Sciences, Changchun)
An experimental model of osteomalacic skeletal fluotosis is produced in rats fed with a monotonous diet using maize as the staple food and offered distilled water supplemented with 200 ppm sodium fluoride for two months. The osteoma-lacia in fluoride toxicity is obviously aggravated by adding ammonium molybdate to the diet and markedly alleviated when the diet is supplemented with serpentine. If adequate calcium is given to the diet, the osteamalacic form of skeletal fluorosis can be prevented. The deficiency of dietary calcium is an essential factor in the development of osteomalacic skeletal fluorosis. Besides reduction of fluoride intake, the supplement of adequate calcium and the improvement of collagen metabolism are the effective approaches to the enhancement of body tolerance to fluoride and the prevention of fluoride-induced osteomalacia.