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《ENDEMIC DISEASES BULLETIN (CHINA)》 2000-03
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Experimental Infection of Echinococcus granulosus and Echinococcus multilocularis in Cricetulus migratorius and Lagurus lagurus

Israyil·OSMAN, JIAO Wei, LIAO Li fu, et al. (National Hydatid Disease Centre of China, Xinjiang Institute for Endemic Disease Control and Research, Urumqi, Xinjiang 830002, China)  
The Cricetulus migratorius and Lagurus lagurus were experimentaly infected with protoscolices of metacestodes of E.granulosus and E.multilocularis by intraperitoneal infection and with NIH mice and BALB/c mice as control animal. The infection rates of E.granulosus were 31% (37/118) in C.migratorius, 21%(6/28) in L.lagurus, 97%(30/31) in NIH mice and 89% (39/44) in BALB/c mice. Development of secondary cysts in former two species of wild rodents were obviously behind the latter two strains of mice. C.migratorius and L. lagurus are sensitive to infection of protoscolices of E.moltilocularis. The wet weight of cysts in C.migratorius were (0.22±0.15)g and (1.14±0.46)g respectively at the 25th day and the 60th day after inoculation. The mature protoscolex was found at the 41th day. The wet weight of L.lagurus were 0.01g and (0.56±0.18)g at the 25th day and the 60th day after inoculation respectively. The mature protoscolex were found at the 49th day in tissue section and the 60th day on homogenate deposit smears of cyst tissues. The wet weight of cysts in NIH mice was reached to (0.53±0.44)g until the 90th day after inoculation and without mature protoscolex. The results indicates that the C.migratorius and L.lagurus are very sensitive to E.multilocu laris and suitable to establishment of animal models in alveolar echinococcosis.
【Fund】: 新疆卫生厅青年科技人才专项科研基金!(97Y0 1 8 )
【CateGory Index】: R383.3
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