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《Electrochemistry》 2009-03
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The Electrochemical Behavior of Daunorubicin Hydrochloride on Galactic Disk Electrode and its Reaction with BSA

CHENG Hong-fen,ZHang Yong,LIU Jie,LIU Yan-mei(School of Chemistry and Chemical Engineering,Shanxi University,Taiyuan 030006,China)  
This article used the linear sweep voltammetry and the circulation voltammetry to study the electrochemical behavior of daunorubicin hydrochloride on galactic disk electrode and its electrode reaction with BSA.Also it studied the interaction of daunorubicin hydrochloride with BSA.The results showed that daunorubicin hydrochloride has a sensitive reduction peak at -0.64 V(vs. SCE) in pH 6.50 Britton-Robinson buffer.The valus of reductions peak current reduced by the addition of BSA to the above mentioned solution.A new electrochemical determination method of bovine serum albumin was developed based on the interaction of daunorubicin hydrochloride with BSA.Furthermore,under the optimized condition,the decrease of the reduction peak current of daunorubicin hydrochloride is proportional to the concentration of BSA in the range of 5.0×10-8 mol·L-1~1.0×10-4 mol·L-1(r=0.9965).The limit of detection is 5.0×10-9 mol·L-1.The binding ratio and binding constant of daunorubicin hydrochloride with BSA were calculated.
【Fund】: 国家自然科学基金(20375024);; 山西省青年科技基金(20021008)资助
【CateGory Index】: R927;R96
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