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《Electrochemistry》 2011-01
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Interaction of the Epirubicin Hydrochloride with Bovine Serum Albumin and Its Application

CHENG Hong-fen,ZHANG Yong,SONG Jie-qiong,WANG Zeng-qiao (School of Chemistry and Chemical Engineering,Shanxi University,Taiyuan 030006,China)  
The linear sweep technique was used to study the electrochemical behavior of epirubicin hydrochloride.The results showed that there was a sensitive reduction peak at-0.34 V(vs.SCE) in pH 6.80 Tris-HCl buffer.When the BSA was added,the value of the reduction peak was reduced deeply.Accordingly,a new electrchemical determintation method of BSA was established.Under the optimum conditions,the decrease of the reduction peak currents of epirubicin hydrochloride were proportional to the concentrations of BSA in the range of 1.0×10-9~1.0×10-6 mol·L-1(R=0.9973).The detection limit of the BSA was 8.05×10-10 mol·L-1.And the binding constant β of the epirubicin hydrochloride and BSA was 3.04×106 L·mol-1 with the ratio of 1.
【Fund】: 国家自然科学基金项目(20375024);; 山西省青年科技基金项目(20021008)资助
【CateGory Index】: R914
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Chinese Journal Full-text Database 1 Hits
1 PENG Zhen~(*1,2),CHENG Le-hua~(1),LU Guang-han~(2)(1.Department of Chemistry,Chaohu College,Chaohu,Anhui 238000;2.College of Chemistry,Central China Normal University,Wuhan 430079);Electrochemical Study of Rhodamine B Interacting with Bovine Serum Albumin(BSA)[J];Journal of Analytical Science;2006-03
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