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《Chinese Journal of Medicinal Guide》 2003-06
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Effect of Recombinant Human Erythropoietin on Nitric Oxide, Endothelin-1 in Chronic Hemodiaiysis Patients

Wang Cai-li, Ma Xiao-Ian, Yin Mei-li, et al. (Division of Nephrology,The First Affiliated of Baotou Medical College,Baotou 014010)  
Objective: To investigate the effect of recorabinant Human erythropoietin(rhuEpo) on Nitric Oxide (NO) and Endothelih-l(ET-l) in ehroic hemodialysis patients. Methods:Eighty patients on chronic hemodialysis were involoved in the randomized, controlled observation. Forty three received rhuEpo(HDepo n=43), thirty seven did not(HD n=37). According to the blood pressure of these patients, each group was divided into two groups further, HDepo with hypertension (HDepo-1 group, n=23), HDepo with normal blood pressure (HDepo-2group, n=20), HD with hypertension(HD-l group,n=19), HD with normal blood pressure (HD-2group,n=18), twenty uremia patients did not receive hemodialysis therapy and twenty primary hypertension patients,thirty-four normal adults were chosen as control group (CON.group). The NO level was detected by colorimetry.The ET-1 level were detected by radioimmunoassary (RIA). Results: The NO level and ET-1 level in serum of uremia patients did not receive HD therapy were significantly higher than those in normal control group (P0.001). The NO level, ET-1 level level in uremia patients receive HD therapy were higher than those in normal control group(P0.05),The No level in serum in hemodialysis patients was higher than those patients who did not receive hemodialysis therapy.The ET-1 level were higher than those patients who did not receive hemodialysis patients.(P0.05).After three months'therapy, the NO consistency in serum in HD group declined after the rHuepo therapy (P0.001), and it was lower than that of normal control group (P0.05).While the ET-1 consistency raised. After the therapy, diastolic pressure, systolic pressure, mean arterial pressure of HDepo group were all higher than those of HD group (P0.001), the rising of blood pressure corrlated with the decline of the NO consistencyjaising of ET-1 consistency. Conclusion: Erythropoietin can reduce the consistency of NO in serum in chronic urinemia hemodialysis patients.It also can increase the ET-1 consistency.Hypertension caused by rhuEpo relate with the decline of the NO consistency, and increase of ET-1 consistency.
【Fund】: 内蒙古卫生厅2001年科研项目2类别24号
【CateGory Index】: R459.5
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