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《Chinese Journal of Medicinal Guide》 2008-01
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Exprimental Study of Lung Cancer by United Test of the Level of NSE、CEA、IL-6R and D-Dimer

Sun De-jun Ma Tong-ying Li Hua-gui Shouguang People Hospital,Shouguang 262700,China  
Objective:To discuss the values of tumor markers in diagnosis and predicting prognosis in lung cancer by united test of NSE,CEA,IL-6R and D-Dimer.Methods:293 cases of lung cancer were selected from December 2002 to November 2006,aging from 38 to 81 years old.The ratio of male to female was 3:1.The patients were divided into four groups:early lung cancer of 98 cases,lately lung cancer of 195 cases;non-small cell lung cancer of 202 cases,small cell lung cancer of 91 cases.Pre-treated patients were 138 cases,post-treated patients were 155 cases.Healthy control group was 300,aging from 35 to 80 years old,the ratio of male to female was 3:1.The level of NSE,CEA,IL-6R and D-Dimer were determined by ELISA.Results:The level of NSE,CEA and IL-6R had significantly difference between the patients in early lung cancer group and control group(P0.01),while D-Dimer was not significantly difference(P0.05).The level of NSE,CEA,IL-6 R and D-Dimer in advanced lung cancer was higher than those in early lung cancer(P0.01) .The level of CEA,IL-6R and D-Dimer in non-small cell lung cancer group was higher than those in small cell lung canc- er group(P0.01),while NSE was lower.The level of NSE,CEA and IL-6R of pre-treated patients was higher than those of post-treated patients(P0.01).The positive diagnosis rate were 81.6%(when four indexes were tested in the same time),78.2%(when NSE,CEA and IL-6R were tested),61.8%(when NSE and CEA were tested),and 48.5 (when NSE were tested).Conclusion:While NSE,CEA,IL-6R and D-Dimer were unite tested,there is a higher positive diagnosis.And the measurement of the tumor markers is helpful to determine lung cancer type,diagnose lung cancer ear- ly,and observe the information of illness development.
【CateGory Index】: R734.2
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