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《Chinese Journal of Medicinal Guide》 2008-08
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The Preparation of Microcapsule Tetracycline and Their Performance Parameters' Evaluation

Zhao Pei-jin~1,Jia Fang~2 (1 Cangzhou Medical College,Cangzhou 061001,China; 2 Cangzhou Entry-Exit Inspection and Quarantine Bureau,Cangzhou 061001,China)  
Objective:Tetracycline were mictocapsuled by using Ethylcellulose and Alginate as core material.The release in vitro of microcapsulation product were studied.Method:Two technics of microcapsulation were adapted in che first sealing process.One was thermal phase separation method,the other one was enveloped through the organic solvent evaporation method.The products were resealed by using vigor finestra-drying bath.Result:The size of particles was around 500μm,The encapsulation rate was around 33%.The drug content was around 80%.The release time ingredient in the pellets of active was around 16h.Conclusion:The sustained releasing efficiency of microcapsulation product is higher.
【CateGory Index】: R943
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