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《Chinese Journal of Medicinal Guide》 2008-09
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Clinical Study on Docetaxel Combining Cisplatin and 5-Fluotreating Advanced Gastric Cancer

Zhang Wen-xia,Li Ji-jun (Department of oncology,Cangzhou central Hospital,Hebei,Cangzhou 061001,China)  
Objective:To evaluate the clinical effects and toxicity of DCF reginen(docetaxel plus 5-fluorouracil and cisplatin)chemotherapy in the treatment of advanced gastric cancer(AGC).Methdos:Twenty-seven patients with AGC treated with DCF regimen.Results:27 patients were evaluated with clinical response,including CR 2(7.4%),PR 14(51.8%),SD 8(29.6%),PD 3(11.5%).The totle effective rate was 59.2%. Median time to progression(TIP)was 6.4 months and median over all survival time was 10.2 months.The main side effects were:suppression of bone marrow in 22 patients(81.5%),nausea/vomiting in 23(85.2%),diarihea in 12(44.4%)and stomatitis in 9(42.3%).There was no death during the treatment.Conclusions:DCF reginen chemotherapy was well tolerated regimen in the treatment of AGC,which can relieve suffering and improve quality of life of patients.It can be used as the first-line therapy for relapsed advanced gastric cancer.
【CateGory Index】: R735.2
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Chinese Journal Full-text Database 1 Hits
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