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《Chinese Journal of Medicinal Guide》 2012-01
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Preliminary Analysis of Polysorbate 80 Induced Docetaxel Injection's Abnormal Phenomenon

Zhang Weidong(General Hospital of Beijing Military District,Beijing 100700,China)  
Objective:To determine the cause of Docetaxel injection's abnormal phenomenon and give advice.Methods:Find out the major influence factor by comprehensive analysis of the supplementary materials,processing technique,storage and so on.In addition,via the designed experiment,determine the crucial standards and qualifications.Results:The fatty acids closely related to polysorbate 80's quality and solidifying point are oleic acid and palmitoleic acid.The higher content of oleic acid,and the lower content of palmitoleic acid,polysorbate 80's quality will be better,and solidifying point will be lower.Conclusion:Docetaxel injection's abnormal phenomenon was induced by the quality of polysorbate 80,whose fatty acid composition and solidifying point are the crucial standards.The qualifications could be oleic acid content more than 80%,palmitoleic acid content less than 0.1%,solidifying point less than-5℃.
【CateGory Index】: R943
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【Citations】
Chinese Journal Full-text Database 6 Hits
1 Zhang Wen-xia,Li Ji-jun (Department of oncology,Cangzhou central Hospital,Hebei,Cangzhou 061001,China);Clinical Study on Docetaxel Combining Cisplatin and 5-Fluotreating Advanced Gastric Cancer[J];Chinese Journal of Medicinal Guide;2008-09
2 Qiao Weihong Li Huamin Zhang Shubiao Li Zongshi;Study on the Purification of Oleic Acid[J];DETERGENT & COSMETICS;1999-S1
3 LI Jian1,XIE Jun2,HUANG Chun-yu2,TANG Wei-guo2,ZHOU Jian-ping1 1Department of Pharmaceutics,China Pharmaceutical University,Nanjing 210009;2Jinling Pharmaceutical Technology Center Co.,Ltd,Nanjing 210009,China;Study on Fatty Acids Composition and Refining Methods of Polysorbate 80[J];Pharmaceutical and Clinical Research;2010-01
4 Qi Yun1,Liu Jie2,Zhang Tao3(1.Southwest Pharmaceutical Co.Ltd.Chongqing,China 400038;2.Chongqing Medical University,Chongqing,China 400016; 3.Chongqing Research Institute of Pharmaceutical Industry·Chongqing Engineeri ng Research Center for Chemical Pharmaceutical,Chongqing,China 400061);Research Advances of Antineoplastic Preparations of Taxanes[J];China Pharmaceuticals;2010-04
5 Wu Yi1,2, Jin Shaohong1 (1National Institute for the Control of Pharmaceutical and Biological Products, Beijing 100050; 2School of Pharmacy China Pharmaceutical University);Progress of Pharmacological Properties,Pharmacokinetics Properties and Analytic Method of Pharmaceutical Adjuvant Tween 80[J];Chinese Pharmaceutical Affairs;2008-08
6 Ma Hongyan1,Li Xia1,Zhang Haiyan2,Zhang Mingling2 and Yang Ming1,2(1Chengdu University of Traditional Chinese Medicine,Chengdu 610075;2Key Laboratory of Modern Preparation of Traditional Chinese Medicine);Progress of the Physical and Chemistry Properties about Tween-80 as the Solubilization Adjuvant in TCM Injections[J];Chinese Pharmaceutical Affairs;2010-06
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 ZHAO Zhi-gang(Historical Culture College,Beihua University,Jilin,Jilin 132013);Analysis and Evaluation on Fatty Acid Composition of Hickory Nut Oil[J];Journal of Anhui Agricultural Sciences;2009-06
2 LI Jie-yu et al(Department of Pharmaceutics,Hunan University of Traditional Chinese Medicine,Changsha,Hunan 410208);Optimization of Reflux Extraction Process for Toosendanin from FRUCTUS TOOSENDAN[J];Journal of Anhui Agricultural Sciences;2011-08
3 YANG Yue-e et al(College of Pharmacy,Dali University,Dali,Yunnan 671000);Determination of Five Anthraquinones in RADIX ET RHIZOMA RHEI from Genuine Producing Area[J];Journal of Anhui Agricultural Sciences;2011-11
4 LIU Yong et al(Jiangxi University of Traditional Chinese Medicine,Nanchang,Jiangxi 330006);Comparison Study on Pollen Morphology of Wild Eructus rutaecarpa(Juss.) Benth and E. rutaecarpa(Juss.) Benth.var.officinalis(Dode) Huang in Jiangxi[J];Journal of Anhui Agricultural Sciences;2011-11
5 ZHOU Ping et al(College of Pharmacy,Dali University,Dali,Yunnan 671000);Determination the Content of Astragaloside Ⅳ in Dreg of RADIX ASTRAGALI[J];Journal of Anhui Agricultural Sciences;2011-13
6 HE Rui et al(Research Centre of Chinese Herbal Resource Science and Engineering,Guangzhou University of Chinese Medicine,Key Laboratory of Chinese Medicine Resources of Ministry of Education,Higher Education Megacentre,Guangzhou,Guangdong 510006);Study on the Grading Standard of Andrographis paniculata Seeds[J];Journal of Anhui Agricultural Sciences;2011-24
7 YANG Fan et al(The Department of Chemistry,Changchun Normal University,Changchun,Jilin 130032);Optimization of the Extraction Technology of Total Alkanoids from Radix Sophorae Tonkinensis with Ultrasonic Extraction Technology[J];Journal of Anhui Agricultural Sciences;2011-29
8 WANG Fu-yuan et al(Higher Vocational and technical School,China Pharmaceutical University,Nanjing,Jiangsu 211198);Study on the Preparation Technique on Synthetic Seeds of Atractylodes macrocephala Koidz.[J];Journal of Anhui Agricultural Sciences;2012-02
9 RAO Jun-feng et al(Hangzhou Vocational and Technical College,Hangzhou,Zhejiang 310018);High-quality and High-yield Cultivation Technique of Two Segments Method for Crocus sativus L.in Zhejiang Province[J];Journal of Anhui Agricultural Sciences;2012-09
10 WANG Jin-ming et al(Shanxi Zhendong Daodi Drugs Development Co.,Ltd.,Changzhi,Shanxi 047100);Resources Survey and Analysis of Wild Forsythia suspensa(Thunb.)Vahl[J];Journal of Anhui Agricultural Sciences;2012-15
China Proceedings of conference Full-text Database 9 Hits
1 Wan Yan Henan University of Traditional Chinese Medicine,Zhengzhou,Henan,China 450008;Determination of Astragaloside Ⅳ in astragalus by HPLC-ELSD[A];[C];2012
2 Qunying Mao~1,Zengbing Guo~2,Chunsheng Hao~3,Dan Yu~4,Xiuling Li~3,Zhenglun Liang~1;The study of the standard virus candidate strain for Enterovirus 71 neutralization antibOdy determination[A];[C];2011
3 CHEN Zan-min,CHEN Ying-jiang (Hainan Provincial Institute for Drug Control,Haikou 511002 China);Determination of Ethylenediamine in Aminophyline by Capillary Gas Chromatography[A];[C];2010
4 ZHANG Ai-wu,LIU Le-le,LUO Su-qin,et al. (Department of Pharmacy,Affiliated Hospital,Inner Mongolia Medical College,Hohhot 010050 China);DETERMINATION OF FERULIC ACID IN MALVAE FRUCTUS BY HPLC[A];[C];2010
5 Zhou Junhui Liu Guoyu Zhang Lei Wang Daqi (Xi'an Botanical Garden,Institute of Botany of Shaanxi Province,Xi'an,Shaanxi 710061);Purification Technology of Aesculin and Fraxin from Fraxinus stylosa Lingelsh.[A];[C];2011
6 ZHAO Meng~(1,2),WEI Shuo-nan~1,HU Zheng-hai~(1*) (1.College of Life Science,Northwest University,Xi'an 710069,China; 2.Shanxi Normal University,Linfen 041004,China);Pharmacognostical Studies on Dry Lacquer and Calined Dry Lacquer[A];[C];2010
7 Hengqiang Zhao~1,Yanling Geng~1,Jinpeng Yuan~1,Qinghua Cui~2,Xiao Wang~1,Jianhua Liu~1 (1.Shandong Analysis and Test Center,Shandong Academy of Sciences,Key Laboratory for Applied Technology of Sophisticated Analytical Instruments of Shandong Province,Jinan 250014,China; 2.College of Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan 250355,China);Determination of cAMP in fructus jujubae by UAE-HILIC-DAD-ESI-Q-TOF/MS[A];[C];2012
8 ZHANG Li,DUAN Jinao,DING Anwei (Jiangsu Key Laboratory for High Technology Research of TCM Formulae,Nanjing University of Chinese Medicine Nanjing 210046,China);The Subsequent Revision of Standard of Chinese Pharmacopoeia 2010 Edition VolumeⅠof Thinking by the Provisions of The Crude Drugs Standards of The Japanese Pharmacopoeia 16~(th) Edition[A];[C];2012
9 ;Analysis of and Countermeasure to common medication consultations from dermatology patients[A];[C];2013
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 CHEN Da Bing, LU Wan Liang,YANG Tian Zhi, LI Jing, ZHANG Qiang (Department of Pharmaceutics, Peking University School of Pharmaceutical Sciences, Beijing 100083, China);Preparation and characterization of long-circulating solid lipid nanoparticles containing paclitaxel[J];Journal of Beijing Medical University;2002-01
2 Wang Hongli; Li Zheng; Zhao Junwu(Xi'an Jiaotong University, Xi'an, 710049);ON MEASURING LIQUID VISCOSITY[J];PHYSICAL EXPERIMENT OF COLLEGE;1994-02
3 Wu Ruilan(Shandong University of Technology, Jinan, 250061);A STUDY OF MEASURING LIQUID VISCOSITY BY BALL-DROPPING METHOD[J];PHYSICAL EXPERIMENT OF COLLEGE;1996-03
4 ZHUO Li\|juan\+1, SHI Zuo\|lin\+2, GAO Mei\|qin\+1, LI Yan\|hui\+2, ZHENG Wei\+1 1.Division of Pathology, Fujian Medical University, Fuzhou 350004, China 2.Department of Pathology, Fujian Province Hospital, Fuzhou 350001, China;Expression of Thymidylate Synthase in Gastric Carcinoma and its Clinicopathological Significance[J];Journal of Fujian Medical University;2003-02
5 JIN Gu and KAN Jia yi (Department of Chemistry,University of Science and Technology of China, Hefei 230026);Effect of small molecule hydrocarbon on liquid solid separation of Tween 80-salt-water[J];Analytical Laboratory;2001-04
6 WANG Cai-xia,FENG Xia,XU Fang,LIN Bao-rui(School of Sciences,Tianjin University,Tianjin 300072,China);Preparation of Paclitaxel-Loaded Polymeric Micelles by Dialysis Method[J];Chemical Industry and Engineering;2007-01
7 Zhang Jinhua,Tang Jian (7);Purification and Identification of Surfactants[J];CHEMISTRY;1999-04
8 XIE Hong-lu,ZHANG Qiang,ZHANG Zhi-cai,GONG Shu-sheng,WU Ju,WANG Jun (Department of Chemistry,West Anhui University,Lu'an 237012,Anhui China);The Relationship of Viscosity and Temperature of Tween 80 Measured by Rotational Method[J];Journal of Jishou University(Natural Science Edition);2003-04
9 Zhou Jiahua, Cui Yingde and Wu Yahong (Faculty of Chemical Engineering and Light Industry, Guangdong University of Technology,Guang Zhou, 510090);MEASUREMENT AND CALCULATION OF HLB VALUE OF SURFACTANTS Ⅱ.The Calculation of HLB Value[J];Speciality Petrochemicals;2001-04
10 Feng Wenyu,et al Pharmacy Research Institute,Luzhou Medical College;RESEARCH ON TOXICITY OF CHINESE DRUG INJECTION CONTAINING POLYSORBATE 80 FTO DIFFERENT ANIMALS[J];Journal of Luzhou Medical College;2007-02
China Proceedings of conference Full-text Database 1 Hits
1 FENG Wen-yu 1 LIU Min-hua 2 XIAO Sun-han 2 HE Bing 1 ( 1.Pharmacy Research Institute of Luzhou Medical College, 2.Pharmacy Research College of Luzhou Medical College Luchou City 646000 );Research on Toxicity of Chinese Drug Injection Containing Polysorbate 80 for different Animals[A];[C];2006
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